Cell death proteins in sepsis: key players and modern therapeutic approaches

被引：4
作者：
Yang, Chloe S. [1 ]
Coopersmith, Craig M. [1 ,2 ]
Lyons, John D. [1 ,2 ]
机构：
[1] Emory Univ, Dept Surg, Atlanta, GA 30322 USA
[2] Emory Univ, Emory Crit Care Ctr, Atlanta, GA 30322 USA
来源：
FRONTIERS IN IMMUNOLOGY | 2024年 / 14卷
关键词：
sepsis; cell death; apoptosis; necroptosis; pyroptosis; inflammation; DECREASES LYMPHOCYTE APOPTOSIS; IMPROVES SURVIVAL; INFLAMMASOME ACTIVATION; POLYMICROBIAL SEPSIS; PROGRAMMED NECROSIS; IN-VIVO; INHIBITION; SIRNA; NECROPTOSIS; CASPASES;
D O I：
10.3389/fimmu.2023.1347401
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Cell death proteins play a central role in host immune signaling during sepsis. These interconnected mechanisms trigger cell demise via apoptosis, necroptosis, and pyroptosis while also driving inflammatory signaling. Targeting cell death mediators with novel therapies may correct the dysregulated inflammation seen during sepsis and improve outcomes for septic patients.
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页数：8
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