Synthesis and Anti-convulsant Activity of 1-[3-(4-Amin ophenyl)-3-Oxopropanoyl]- 5,5-Diphenyl imidazolidine-2,4-Dione and its Derivatives

Background: A heterocyclic hydrocarbon with distinct fundamental structural features in its molecular structure of 5, 5-diphenylimidazolidine heterocyclic ring. It is an imidazolidine and aromatic dibenzene fused ring. The flexible heterocyclic compounds that contain two atoms of nitrogen in 5, 5-diphenylimidazolidine. 5, 5-diphenylimidazolidine ring and its derivatives have a robust and promising biological action. In this study, we create a number of 1-[3-(4-ami nophenyl)-3-oxopropanoyl] derivatives. A compound with anticonvulsant properties is-5, 5-diphenylimidazolidine-2,4-dione (AC1). The Strychnine Induced Convulsion Method was used to test the pharmacological samples for anticonvulsant action. The compound 5,5-diphenylimidazolidine-2,4-dione was synthesized together with its 14 total derivatives. Materials and Methods: Benzoin; Benzil; Urea; Glacial Acetic Acid; 4-amino benzoic acid; Con. HNO3; Formic Acid; 2-Nitro Aniline; 4-Nitro Aniline; Aniline; Acetyl Chloride; Formic Acid; 4-amino Phenol are used for the synthesis. IR, NMR and MS are used for interpretation. Results: Our research led us to the conclusion that a variety of compounds have strong anti-convulsant properties. The compound 5,5-diphenylimidazolidine-2,4-dione (AB); 1-acetyl-5,5-diphenylimidazolidine-2,4-dione (AC); 1-[3-(4-hydroxy-2-[2-oxo-4 (phenylamino) ethyl]butanedioicacid)-3-oxopropanoyl]-5,5-diphenylimidazolidine-2,4-dione (AC5); 1-[3-(4-oxo-4-(oxo(4-phenylamino)-3-oxopropanoyl]-5,5-diphenylimidazolidine-2,4-dione (AC6); 1-[3-(4-(phenyl amino)benzoic acid)-3-oxopropanoyl]-5,5-diphenylimidazolidine-2,4-dione (AC7) gives strong anti-convulsant effects against phenytoin drug. Conclusion: The title compounds and its derivatives were examined for their ability to treat convulsion. Studies of the relationship between structure and activity revealed that compounds containing 5, 5-diphenylimidazolidine derivatives that have an electron-withdrawing group have higher activity than those that have an electron-donating group.