Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation

被引：21

作者：

Qian, Frank ^{[1
,2
]}

Tintle, Nathan ^{[3
,4
]}

Jensen, Paul N. ^{[5
]}

Lemaitre, Rozenn N. ^{[5
]}

Imamura, Fumiaki ^{[6
]}

Feldreich, Tobias Rudholm ^{[7
,8
]}

Nomura, Sarah Oppeneer ^{[9
]}

Guan, Weihua ^{[10
]}

Laguzzi, Federica ^{[11
]}

Kim, Eunjung ^{[12
]}

Virtanen, Jyrki K. ^{[13
]}

Steur, Marinka ^{[14
]}

Bork, Christian S. ^{[15
]}

Hirakawa, Yoichiro ^{[16
]}

O'Donoghue, Michelle L. ^{[17
]}

Sala-Vila, Aleix ^{[4
,18
]}

Korat, Andres V. Ardisson ^{[19
]}

Sun, Qi ^{[1
,20
]}

Rimm, Eric B. ^{[1
]}

Psaty, Bruce M. ^{[21
,22
]}

Heckbert, Susan R. ^{[22
]}

Forouhi, Nita G. ^{[6
]}

Wareham, Nicholas J. ^{[6
]}

Marklund, Matti ^{[23
,24
,25
]}

Riserus, Ulf ^{[23
]}

Lind, Lars ^{[26
]}

Arnlov, Johan ^{[27
,28
,29
,30
]}

Garg, Parveen ^{[31
]}

Tsai, Michael Y. ^{[9
]}

Pankow, James ^{[32
]}

Misialek, Jeffrey R. ^{[32
]}

Gigante, Bruna ^{[33
]}

Leander, Karin ^{[11
]}

Pester, Julie A. ^{[34
]}

Albert, Christine M. ^{[35
]}

Kavousi, Maryam ^{[14
]}

Ikram, Arfan ^{[14
]}

Voortman, Trudy ^{[14
,36
]}

Schmidt, Erik B. ^{[37
]}

Ninomiya, Toshiharu ^{[38
,39
]}

Morrow, David A. ^{[17
]}

Bayes-Genis, Antoni ^{[40
,41
,42
]}

O'Keefe, James H. ^{[43
]}

Ong, Kwok Leung ^{[45
]}

Wu, Jason H. Y. ^{[25
]}

Mozaffarian, Dariush ^{[44
,46
,47
]}

Harris, William S. ^{[4
,48
]}

Siscovick, David S. ^{[49
]}

机构：

[1] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA

[2] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA USA

[3] Dordt Univ, Dept Math & Stat, Sioux Ctr, IA USA

[4] Fatty Acid Res Inst, Sioux Falls, SD USA

[5] Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA

[6] Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England

[7] Dalarna Univ, Sch Hlth & Social Sci, Falun, Sweden

[8] Ctr Clin Res Dalarna, Falun, Sweden

[9] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN USA

[10] Univ Minnesota, Div Biostat, Minneapolis, MN USA

[11] Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden

[12] Harvard Med Sch, Brigham & Womens Hosp, Div Prevent Med, Boston, MA USA

[13] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland

[14] Univ Med Ctr, Erasmus Med Ctr, Dept Epidemiol, Rotterdam, Netherlands

[15] Aalborg Univ Hosp, Dept Cardiol, Aalborg, Denmark

[16] Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Fukuoka, Japan

[17] Brigham & Womens Hosp, Cardiovasc Div, TIMI Study Grp, Boston, MA USA

[18] Hosp Del Mar Med Res Inst IMIM, Cardiovasc Risk & Nutr, Barcelona, Spain

[19] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA USA

[20] Harvard Med Sch, Brigham & Womens Hosp, Channing Div Network Med, Boston, MA USA

[21] Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA

[22] Univ Washington, Dept Epidemiol, Cardiovasc Hlth Res Unit, Seattle, WA USA

[23] Uppsala Univ, Dept Publ Hlth & Caring Sci, Clin Nutr & Metab, Uppsala, Sweden

[24] Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA USA

[25] Univ New South Wales, George Inst Global Hlth, Fac Med, Sydney, NSW, Australia

[26] Uppsala Univ, Dept Med Sci, Uppsala, Sweden

[27] Center Clin Res Dalarna, Region Dalarna, Falun, Sweden

[28] Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden

[29] Karolinska Inst, Div Family Med & Primary Care, Dept Neurobiol Care Sci & Soc NVS, Stockholm, Sweden

[30] Univ Southern Calif, Div Cardiol, Keck Sch Med, Los Angeles, CA USA

[31] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA

[32] Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden

[33] Brigham & Womens Hosp, Div Prevent Med, Boston, MA USA

[34] Cedars Sinai Med Ctr, Smidt Heart Inst, Dept Cardiol, Los Angeles, CA USA

[35] Wageningen Univ & Res, Div Human Nutr & Hlth, Wageningenn, Netherlands

[36] Aalborg Univ, Dept Clin Med, Aalborg, Denmark

[37] Kyushu Univ, Grad Sch Med Sci, Dept Epidemiol & Publ Hlth, Fukuoka, Japan

[38] Kyushu Univ, Ctr Cohort Studies, Grad Sch Med Sci, Fukuoka, Japan

[39] Hosp Badalona Germans Trias & Pujol, Heart Inst, Dept Cardiol, Barcelona, Spain

[40] Univ Autonoma Barcelona, Dept Med, Barcelona, Spain

[41] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain

[42] Univ Missouri Kansas City, St Lukes Mid Amer Heart Inst, Kansas City, MO USA

[43] Univ Sydney, NHMRC Clin Trials Ctr, Sydney, NSW, Australia

[44] Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA USA

[45] Tufts Med Ctr, Div Cardiol, Boston, MA USA

[46] Univ South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD USA

[47] New York Acad Med, New York, NY USA

[48] Univ Washington, Dept Epidemiol, Cardiovasc Hlth Res Unit, Seattle, WA USA

[49] Univ Washington, Dept Hlth Syst & Populat Hlth, Cardiovasc Hlth Res Unit, Seattle, WA USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2023年 / 82卷 / 04期

关键词：

KEY WORDS biomarkers; docosapentaenoic acid; docosahexaenoic acid; eicosapentaenoic acid; observational epidemiology; LONG-CHAIN OMEGA-3-FATTY-ACIDS; POLYUNSATURATED FATTY-ACIDS; POOLING PROJECT; SUPPLEMENTATION; HEART; RISK;

D O I：

10.1016/j.jacc.2023.05.024

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND The relationship between omega-3 fatty acids and atrial fibrillation (AF) remains controversial. OBJECTIVES This study aimed to determine the prospective associations of blood or adipose tissue levels of eicosa-pentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with incident AF. METHODS We used participant-level data from a global consortium of 17 prospective cohort studies, each with baseline data on blood or adipose tissue omega-3 fatty acid levels and AF outcomes. Each participating study conducted a de novo analyses using a prespecified analytical plan with harmonized definitions for exposures, outcome, covariates, and sub-groups. Associations were pooled using inverse-variance weighted meta-analysis. RESULTS Among 54,799 participants from 17 cohorts, 7,720 incident cases of AF were ascertained after a median 13.3 years of follow-up. In multivariable analysis, EPA levels were not associated with incident AF, HR per interquintile range (ie, the difference between the 90th and 10th percentiles) was 1.00 (95% CI: 0.95-1.05). HRs for higher levels of DPA, DHA, and EPA+DHA, were 0.89 (95% CI: 0.83-0.95), 0.90 (95% CI: 0.85-0.96), and 0.93 (95% CI: 0.87-0.99), respectively. CONCLUSIONS In vivo levels of omega-3 fatty acids including EPA, DPA, DHA, and EPA+DHA were not associated with increased risk of incident AF. Our data suggest the safety of habitual dietary intakes of omega-3 fatty acids with respect to AF risk. Coupled with the known benefits of these fatty acids in the prevention of adverse coronary events, our study suggests that current dietary guidelines recommending fish/omega-3 fatty acid consumption can be maintained. (J Am Coll Cardiol 2023;82:336-349) & COPY; 2023 by the American College of Cardiology Foundation.

引用

页码：336 / 349

页数：14

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