A novel electrochemical aptasensor based on eco-friendly synthesized titanium dioxide nanosheets and polyethyleneimine grafted reduced graphene oxide for ultrasensitive and selective detection of ciprofloxacin

被引:14
作者
Zhu, Yangguang [1 ,2 ]
Li, Xiufen [1 ]
Wu, Mengfan [2 ]
Shi, Mingjiao [2 ]
Tian, Qichen [2 ]
Fu, Li [3 ]
Tsai, Hsu-Sheng [4 ]
Xie, Wan-Feng [5 ]
Lai, Guosong [6 ]
Wang, Gang [7 ]
Jiang, Nan [2 ,8 ,9 ]
Ye, Chen [2 ]
Lin, Cheng-Te [2 ]
机构
[1] Jiangnan Univ, Sch Environm & Civil Engn, Lab Environm Biotechnol, Wuxi 214122, Peoples R China
[2] Chinese Acad Sci, Qianwan Inst, Ningbo Inst Mat Technol & Engn NIMTE, Ningbo 315201, Peoples R China
[3] Hangzhou Dianzi Univ, Coll Mat & Environm Engn, Hangzhou 310018, Peoples R China
[4] Harbin Inst Technol, Lab Space Environm & Phys Sci, Harbin 150001, Peoples R China
[5] Qingdao Univ, Coll Elect & Informat, Univ Ind Joint Ctr Ocean Observat & Broadband Comm, Qingdao 266071, Peoples R China
[6] Hubei Normal Univ, Coll Chem & Chem Engn, Hubei Key Lab Pollutant Anal & Reuse Technol, Huangshi 435002, Peoples R China
[7] Ningbo Univ, Sch Phys Sci & Technol, Dept Microelect Sci & Engn, Ningbo 315211, Peoples R China
[8] Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China
[9] Chinese Acad Sci, Ningbo Inst Mat Technol & Engn NIMTE, Key Lab Marine Mat & Related Technol, Zhejiang Key Lab Marine Mat & Protect Technol, Ningbo 315201, Peoples R China
基金
中国博士后科学基金; 中国国家自然科学基金;
关键词
Ciprofloxacin; Polyethyleneimine; Titanium dioxide nanosheets; Electrochemical aptasensor; Interface charge transferring; LABEL-FREE; SENSITIVE DETECTION; GOLD NANOPARTICLES; RAMAN-SPECTROSCOPY; ORGANIC-DYES; NANOCOMPOSITE; SENSOR; CHLORAMPHENICOL; BIOSENSOR; NANORODS;
D O I
10.1016/j.aca.2023.341607
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Developing a rapid, sensitive, and efficient analytical method for the trace-level determination of highly concerning antibiotic ciprofloxacin (CIP) is desirable to guarantee the safety of human health and ecosystems. In this work, a novel electrochemical aptasensor based on polyethyleneimine grafted reduced graphene oxide and titanium dioxide (rGO/PEI/TiO2) nanocomposite was constructed for ultrasensitive and selective detection of CIP. Through the in-situ electrochemical oxidation of Ti3C2Tx nanosheets, TiO2 nanosheets with good electrochemical response were prepared in a more convenient and eco-friendly method. The prepared TiO2 nanosheets promote charge transferring on electrode interface, and [Fe(CN)6]3-/4- as electrochemical active substance can be electrostatically attracted by rGO/PEI. Thus, electrochemical detection signal of the aptasensor variates a lot after specific binding with CIP, achieving working dynamic range of 0.003-10.0 & mu;mol L-1, low detection limit down to 0.7 nmol L-1 (S/N = 3) and selectivity towards other antibiotics. Additionally, the aptasensor exhibited good agreement with HPLC method at 95% confidence level, and achieved good recoveries (96.8-106.3%) in real water samples, demonstrating its suitable applicability of trace detection of CIP in aquatic environment.
引用
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页数:13
相关论文
共 74 条
[1]   A novel electrochemical aptasensor for ultrasensitive detection of fluoroquinolones based on single-stranded DNA-binding protein [J].
Abnous, Khalil ;
Danesh, Noor Mohammad ;
Alibolandi, Mona ;
Ramezani, Mohammad ;
Taghdisi, Seyed Mohammad ;
Emrani, Ahmad Sarreshtehdar .
SENSORS AND ACTUATORS B-CHEMICAL, 2017, 240 :100-106
[2]   A review on synthesis, optimization, characterization and antibacterial application of gold nanoparticles synthesized from plants [J].
Akintelu, Sunday Adewale ;
Olugbeko, Seyifunmi Charles ;
Folorunso, Aderonke Similoluwa .
INTERNATIONAL NANO LETTERS, 2020, 10 (04) :237-248
[3]   Enhanced efficiency of polyamide membranes by incorporating TiO2-Graphene oxide for water purification [J].
Al-Gamal, Anwar Q. ;
Falath, Wail S. ;
Saleh, Tawfik A. .
JOURNAL OF MOLECULAR LIQUIDS, 2021, 323
[4]   Removal of Lead from Wastewater Using Synthesized Polyethyleneimine-Grafted Graphene Oxide [J].
Al-Yaari, Mohammed ;
Saleh, Tawfik A. .
NANOMATERIALS, 2023, 13 (06)
[5]   Titanium Dioxide Nanomaterials for Sensor Applications [J].
Bai, Jing ;
Zhou, Baoxue .
CHEMICAL REVIEWS, 2014, 114 (19) :10131-10176
[6]   Electrochemical determination of chloramphenicol and metronidazole by using a glassy carbon electrode modified with iron, nitrogen co-doped nanoporous carbon derived from a metal-organic framework (type Fe/ZIF-8) [J].
Baikeli, Yiliyasi ;
Mamat, Xamxikamar ;
He, Fei ;
Xin, Xuelei ;
Li, Yongtao ;
Aisa, Haji Akbar ;
Hu, Guangzhi .
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2020, 204
[7]   Energy loss rates of hot Dirac fermions in epitaxial, exfoliated, and CVD graphene [J].
Baker, A. M. R. ;
Alexander-Webber, J. A. ;
Altebaeumer, T. ;
McMullan, S. D. ;
Janssen, T. J. B. M. ;
Tzalenchuk, A. ;
Lara-Avila, S. ;
Kubatkin, S. ;
Yakimova, R. ;
Lin, C. -T. ;
Li, L. -J. ;
Nicholas, R. J. .
PHYSICAL REVIEW B, 2013, 87 (04)
[8]   Sol-gel synthesis of cubic titanium dioxide nanoparticle using poly(ethylene glycol) as a capping agent: voltammetric simultaneous determination of uric acid and guanine [J].
Biswas, Sudip ;
Pradhan, Susmita ;
Naskar, Hemanta ;
Bandyopadhyay, Rajib ;
Pramanik, Panchanan .
MICROCHIMICA ACTA, 2018, 185 (11)
[9]   A novel electrochemical DNA biosensor based on graphene and polyaniline nanowires [J].
Bo, Yang ;
Yang, Huiyan ;
Hu, Ying ;
Yao, Tianming ;
Huang, Shasheng .
ELECTROCHIMICA ACTA, 2011, 56 (06) :2676-2681
[10]   Synthesis of nitrogen-doped graphene nanosheets decorated with gold nanoparticles as an improved sensor for electrochemical determination of chloramphenicol [J].
Borowiec, Joanna ;
Wang, Rui ;
Zhu, Lihua ;
Zhang, Jingdong .
ELECTROCHIMICA ACTA, 2013, 99 :138-144