Dauricine exhibits anti-inflammatory property against acute ulcerative colitis via the regulation of NF-κB pathway

被引：4

作者：

Zhang, Xu ^{[1
]}

Wang, Ting ^{[2
]}

Miao, Yu ^{[1
]}

Lin, Wan ^{[1
]}

Zhu, Litao ^{[3
]}

Meng, Xiangkun ^{[1
]}

Zhang, Feixiong ^{[1
]}

机构：

[1] Ningxia Med Univ, Gen Hosp, Gastroenterol Dept, 804 Shengli St, Yinchuan 750003, Ningxia, Peoples R China

[2] Ningxia Med Univ Gen Hosp, Grp Off, Yinchuan, Ningxia, Peoples R China

[3] Ningxia Yinchuan Prison Hosp, Outpatient Dept, Yinchuan, Ningxia, Peoples R China

来源：

CELL BIOCHEMISTRY AND FUNCTION | 2023年 / 41卷 / 06期

关键词：

acute ulcerative colitis; dauricine; inflammation; NF-& kappa; B pathway; NF-KAPPA-B;

D O I：

10.1002/cbf.3826

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We aim to investigate the therapeutic effect of dauricine on ulcerative colitis (UC). Our results indicated that dauricine attenuated the reduction of colonic length, weight loss, disease activity index, colonic tissue damage, and inflammatory cytokine levels in dextran sulfate sodium mice. In addition, dauricine reduced lipopolysaccharide-induced inflammation in HT-29 cells. Mechanically, dauricine docked with p65, a member of nuclear transcription factor kappaB (NF-?B) family, through which reduced the inflammatory cytokine release from HT-29 cells. Together, the above results inferred that dauricine had therapeutic effect for UC by suppressing NF-?B pathway, which provided a promising mean for UC treatment.

引用

页码：713 / 721

页数：9

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