3-Quinoline Boric Acid as an Efficient Catalyst for the Direct Amidation of Carboxylic Acids at Room Temperature

3-Quinoline boric acid had been identified as an inexpensive and effective catalyst for the direct dehydrative amide formation of carboxylic acids and amines. The catalyst was applicable to a wide range of carboxylic acids with primary and secondary amines to afford amides in moderate to good yields at room temperature. The catalyst also showed good catalytic activity to some aromatic and heteroaromatic carboxylic acids under higher temperature. This protocol provides a new methodology for the green boron -catalytic amidation under mild conditions.