Current and Novel Biomarkers of Progression Risk in Children with Chronic Kidney Disease

被引：3

作者：

Sandokji, Ibrahim ^{[1
]}

Xu, Yunwen ^{[2
]}

Denburg, Michelle ^{[3
]}

Furth, Susan ^{[3
]}

Abraham, Alison G. ^{[4
]}

Greenberg, Jason H. ^{[5
,6
]}

机构：

[1] Taibah Univ, Coll Med, Dept Pediat, Medina, Saudi Arabia

[2] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[3] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Div Nephrol, Philadelphia, PA USA

[4] Univ Colorado, Dept Epidemiol, Anschutz Med Campus, Aurora, CO USA

[5] Yale Sch Med, Dept Pediat, Sect Nephrol Clin & Translat Res Accelerator, New Haven, CT USA

[6] Yale Univ, Sch Med, 333 Cedar St LMP 3086, New Haven, CT 06520 USA

来源：

NEPHRON | 2023年

关键词：

Chronic kidney disease; Children; Biomarker; Metabolomics; MicroRNA; GLOMERULAR HYPERFILTRATION; TARGETED METABOLOMICS; INJURY MOLECULE-1; FUNCTION DECLINE; ASSOCIATION; DIAGNOSIS; RECEPTOR; MICRORNAS;

D O I：

10.1159/000530918

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Due to the complexity of chronic kidney disease (CKD) pathophysiology, biomarkers representing different mechanistic pathways have been targeted for the study and development of novel biomarkers. The discovery of clinically useful CKD biomarkers would allow for the identification of those children at the highest risk of kidney function decline for timely interventions and enrollment in clinical trials. Summary: Glomerular filtration rate and proteinuria are traditional biomarkers to classify and prognosticate CKD progression in clinical practice but have several limitations. Over the recent decades, novel biomarkers have been identified from blood or urine with metabolomic screening studies, proteomic screening studies, and an improved knowledge of CKD pathophysiology. This review highlights promising biomarkers associated with the progression of CKD that could potentially serve as future prognostic markers in children with CKD. Key Messages: Further studies are needed in children with CKD to validate putative biomarkers, particularly candidate proteins and metabolites, for improving clinical management.

引用

页码：1 / 10

页数：18

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