Plant molecular farming in the wake of the closure of Medicago Inc

被引:18
作者
Benvenuto, Eugenio [1 ]
Broer, Inge [2 ]
D'Aoust, Marc-Andre [3 ]
Hitzeroth, Inga [4 ]
Hundleby, Penny [5 ]
Menassa, Rima [6 ]
Oksman-Caldentey, Kirsi-Marja [7 ]
Peyret, Hadrien [5 ]
Salgueiro, Sancha [8 ]
Saxena, Pooja [9 ]
Stander, Jennifer [10 ]
Warzecha, Heribert [11 ]
Ma, Julian [12 ]
机构
[1] Ctr Ric Casaccia, ENEA, Dept Sustainabil, Biotechnol & Agroind Div, Rome, Italy
[2] Univ Rostock, Fac Agr & Environm Sci, Rostock, Germany
[3] Medicago R&D, Quebec City, PQ, Canada
[4] Univ Cape Town, Dept Mol & Cell Biol, BioPharming Res Unit, Cape Town, South Africa
[5] John Innes Ctr, Norwich, Norfolk, England
[6] Univ Western Ontario, London, ON, Canada
[7] VTT Tech Res Ctr Finland, Espoo, Finland
[8] Chart Biotechnol, Gilleleje, Denmark
[9] BlueRock Therapeut, Toronto, ON, Canada
[10] Cape Bio Pharms, Cape Town, South Africa
[11] Tech Univ Darmstadt, Darmstadt, Germany
[12] St Georges Univ London, London, England
基金
英国生物技术与生命科学研究理事会;
关键词
MONOCLONAL-ANTIBODY;
D O I
10.1038/s41587-023-01812-w
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
引用
收藏
页码:893 / 894
页数:2
相关论文
共 17 条
[1]   Very-large-scale production of antibodies in plants: The biologization of manufacturing [J].
Buyel, J. F. ;
Twyman, R. M. ;
Fischer, R. .
BIOTECHNOLOGY ADVANCES, 2017, 35 (04) :458-465
[2]   Extraction and downstream processing of plant-derived recombinant proteins [J].
Buyel, J. F. ;
Twyman, R. M. ;
Fischer, R. .
BIOTECHNOLOGY ADVANCES, 2015, 33 (06) :902-913
[3]  
ClinicalTrials.gov, 2021, PREVENT COVID 19 Q G
[4]  
ClinicalTrials.gov, 2020, KBP 201 COVID 19 VAC
[5]   Molecular farming - The slope of enlightenment [J].
Fischer, Rainer ;
Buyel, Johannes F. .
BIOTECHNOLOGY ADVANCES, 2020, 40
[6]   Pharmacokinetics, pharmacodynamics, and safety of moss-aGalactosidase A in patients with Fabry disease [J].
Hennermann, Julia B. ;
Arash-Kaps, Laila ;
Fekete, Gyorgy ;
Schaaf, Andreas ;
Busch, Andreas ;
Frischmuth, Thomas .
JOURNAL OF INHERITED METABOLIC DISEASE, 2019, 42 (03) :527-533
[7]   PRODUCTION OF ANTIBODIES IN TRANSGENIC PLANTS [J].
HIATT, A ;
CAFFERKEY, R ;
BOWDISH, K .
NATURE, 1989, 342 (6245) :76-78
[8]   A randomized, double-blind, placebo-controlled, dose-escalating phase I trial to evaluate safety and immunogenicity of a plant-produced, bivalent, recombinant norovirus-like particle vaccine [J].
Leroux-Roels, Isabel ;
Maes, Cathy ;
Joye, Jasper ;
Jacobs, Bart ;
Jarczowski, Franziska ;
Diessner, Andre ;
Janssens, Yorick ;
Waerlop, Gwenn ;
Tamminen, Kirsi ;
Heinimaki, Suvi ;
Blazevic, Vesna ;
Leroux-Roels, Geert ;
Klimyuk, Victor ;
Adachi, Hiroshi ;
Hiruta, Kazuyuki ;
Thieme, Frank .
FRONTIERS IN IMMUNOLOGY, 2022, 13
[9]   The production of recombinant pharmaceutical proteins in plants [J].
Ma, JKC ;
Drake, PMW ;
Christou, P .
NATURE REVIEWS GENETICS, 2003, 4 (10) :794-805
[10]   Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants [J].
Ma, Julian K-C. ;
Drossard, Juergen ;
Lewis, David ;
Altmann, Friedrich ;
Boyle, Julia ;
Christou, Paul ;
Cole, Tom ;
Dale, Philip ;
van Dolleweerd, Craig J. ;
Isitt, Valerie ;
Katinger, Dietmar ;
Lobedan, Martin ;
Mertens, Hubert ;
Paul, Mathew J. ;
Rademacher, Thomas ;
Sack, Markus ;
Hundleby, Penelope A. C. ;
Stiegler, Gabriela ;
Stoger, Eva ;
Twyman, Richard M. ;
Vcelar, Brigitta ;
Fischer, Rainer .
PLANT BIOTECHNOLOGY JOURNAL, 2015, 13 (08) :1106-1120