Cancer stem cells in colorectal cancer: Signaling pathways involved in stemness and therapy resistance

被引：57

作者：

Ebrahimi, Nasim ^{[1
]}

Afshinpour, Maral ^{[2
]}

Fakhr, Siavash Seifollahy ^{[3
]}

Kalkhoran, Paniz Ghasempour ^{[4
]}

Shadman-Manesh, Vida ^{[5
]}

Adelian, Samaneh ^{[6
]}

Beiranvand, Sheida ^{[7
]}

Rezaei-Tazangi, Fatemeh ^{[8
]}

Khorram, Roya ^{[9
]}

Hamblin, Michael R. ^{[10
]}

Aref, Amir Reza ^{[11
,12
]}

机构：

[1] Univ Isfahan, Fac Sci & Technol, Dept Cell & Mol & Microbiol, Div Genet, Esfahan, Iran

[2] South Dakota State Univ SDSU, Dept Chem & Biochem, Brookings, SD USA

[3] Fac Appl Ecol Agr Sci & Biotechnol, Dept Biotechnol, Campus Hamar, Hamar, Norway

[4] Islamic Azad Univ, Fac Adv Sci & Technol, Dept Cellular & Mol Biol Microbiol, Tehran Med Sci, Tehran, Iran

[5] Islamic Azad Univ, Dept Biomed Engn, Sci & Res Branch, Tehran, Iran

[6] Shahrekord Univ Med Sci, Basic Hlth Sci Inst, Cellular & Mol Res Ctr, Shahrekord, Iran

[7] Islamic Azad Univ, Sch Basic Sci, Dept Biotechnol, Shahrekord Branch, Shahrekord, Iran

[8] Fasa Univ Med Sci, Sch Med, Dept Anat, Fasa, Iran

[9] Shiraz Univ Med Sci, Bone & Joint Dis Res Ctr, Dept Orthoped Surg, Shiraz, Iran

[10] Univ Johannesburg, Fac Hlth Sci, Laser Res Ctr, ZA-2028 Doornfontein, South Africa

[11] Harvard Med Sch, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[12] Translat Med Grp, Xsphera Biosci, 6 Tide St, Boston, MA 02210 USA

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2023年 / 182卷

关键词：

Cellular metabolism; Cancer stem cells; Signaling pathways; Cancer initiating cells; Drug resistance; Colorectal cancer; NF-KAPPA-B; DRUG-RESISTANCE; BETA-CATENIN; PHENOTYPIC CHARACTERIZATION; TARGETING ST6GALNAC2; TUMOR INITIATION; HEDGEHOG PATHWAY; GENE-EXPRESSION; SELF-RENEWAL; WNT PATHWAY;

D O I：

10.1016/j.critrevonc.2023.103920

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer (CRC) is the third cause of cancer death worldwide. Although, in some cases, treatment can increase patient survival and reduce cancer recurrence, in many cases, tumors can develop resistance to therapy leading to recurrence. One of the main reasons for recurrence and therapy resistance is the presence of cancer stem cells (CSCs). CSCs possess a self-renewal ability, and their stemness properties lead to the avoidance of apoptosis, and allow a new clone of cancer cells to emerge. Numerous investigations inidicated the involvment of cellular signaling pathways in embryonic development, and growth, repair, and maintenance of tissue homeostasis, also participate in the generation and maintenance of stemness in colorectal CSCs. This review discusses the role of Wnt, NF-kappa B, PI3K/AKT/mTOR, Sonic hedgehog, and Notch signaling pathways in colorectal CSCs, and the possible modulating drugs that could be used in treatment for resistant CRC.

引用

页数：15

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