Recent advances in the synthesis of benzo[ b ]thiophene fused polycyclic derivatives: Strategies and reactions

Benzo[b]thiophene fused compounds with a unique active heterocyclic skeleton have wide applica-tions in the fields of medicinal chemistry, organic synthesis, and organic functional materials, which resulted in rapid development of many efficient methods for the construction of benzo[b]thiophene-fused heterocycles in recent years. Among these methods, the domino reaction of benzo[b]thiophene derivatives is a practical and powerful synthetic route to access benzo[b]thiophene-fused heterocy-cles by virtue of the particularity of sulfur atom. This review summarizes the latest developments in the construction of benzo[b]thiophene-fused heterocycles by ring formation at the C2-C3-position of benzo[b]thiophene derivatives in the past decade. Additionally, this review is divided into four parts ac-cording to the four kinds of benzo[b]thiophene derivatives used, including thioaurone, thioisatin, substi-tuted benzo[b]thiophene, and azadiene. (c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.