Synthesis and cytotoxic activity of new hexaazadibenzotetracenes derived from trans-1,2-diaminocyclohexane

被引：2

作者：

Rakhimova, Elena B. ^{[1
]}

Kirsanov, Victor Yu. ^{[1
]}

Kuzmina, Ulyana Sh. ^{[2
]}

Galyautdinov, Ilgiz V. ^{[2
]}

Vakhitova, Yulia V. ^{[2
]}

机构：

[1] Russian Acad Sci, Inst Petrochem & Catalysis, Ufa Fed Res Ctr, Ufa 450075, Russia

[2] Russian Acad Sci, Inst Biochem & Genet, Ufa Fed Res Ctr, Ufa 450054, Russia

来源：

MENDELEEV COMMUNICATIONS | 2023年 / 33卷 / 01期

关键词：

catalysis; heterocyclization; trans-1; 2-diaminocyclohexane; anilines; polycyclic compounds; hexaazadibenzotetracenes; cytotoxic activity; ENANTIOSELECTIVE MICHAEL ADDITIONS; 1,3-DICARBONYL COMPOUNDS; ACIDS;

D O I：

10.1016/j.mencom.2023.01.035

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A one-pot synthesis of N,N'-disubstituted (3bR*,7aR*,1 0bR*,14aR*)-octadecahydro-1H,8H- 2,3a,7b,9,10a,14b-hexaazadibenzo[fg, op]tetracenes via the catalytic heterocyclization of trans-1,6,7,12-tetraaza-perhydrotetracene with formaldehyde or CH2(NMe2)2 and anilines has been accomplished. Preliminary screening of thus obtained perhydro hexaazadibenzotetracenes for cytotoxic activity has been performed.

引用

页码：112 / 114

页数：3

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