5-Imidazolinone Derivatives as a Potent Pharmacological Agents-A Review

被引:4
作者
Sivakumar, B. [1 ]
Ilango, K. [2 ]
机构
[1] SRM Inst Sci & Technol, SRM Coll Pharm, Dept Pharmaceut Chem, Kattankulanthur 603203, Tamil Nadu, India
[2] SRM Inst Sci & Technol, SRM Coll Pharm, Dept Pharmaceut Qual Assurance, Kattankulanthur 603203, Tamil Nadu, India
关键词
5-imidazolinone; structure-activity studies; drug discovery; pharmacological activities; ANTICANCER; IMIDAZOLE; DESIGN;
D O I
10.1134/S1068162023020140
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In clinical medicine, heterocyclic rings like imidazolinone-containing drugs have been discovered to have a wide range of applications. Their unique structural features of imidazolinone derivatives have a wide range of significant pharmacological or biological activities. The pharmaceutical companies frequently perform research and exploit their derivatives for drug discovery. In this work, we examined the progress and structural modification of 5-imidazolinone derivatives in the search for effective anticancer agents; these compounds could be promising anticancer agents with better therapeutic potential for the suppression of tumors. However, 5-imidazolinone derivatives showed anti-bacterial, anti-fungal, anti-diabetic, anti-inflammatory and analgesic activities and also exhibited better in silico and in vitro studies respectively. The specified data may be beneficial for future contrivance.
引用
收藏
页码:167 / 179
页数:13
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