5-Imidazolinone Derivatives as a Potent Pharmacological Agents-A Review

被引:2
|
作者
Sivakumar, B. [1 ]
Ilango, K. [2 ]
机构
[1] SRM Inst Sci & Technol, SRM Coll Pharm, Dept Pharmaceut Chem, Kattankulanthur 603203, Tamil Nadu, India
[2] SRM Inst Sci & Technol, SRM Coll Pharm, Dept Pharmaceut Qual Assurance, Kattankulanthur 603203, Tamil Nadu, India
关键词
5-imidazolinone; structure-activity studies; drug discovery; pharmacological activities; ANTICANCER; IMIDAZOLE; DESIGN;
D O I
10.1134/S1068162023020140
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In clinical medicine, heterocyclic rings like imidazolinone-containing drugs have been discovered to have a wide range of applications. Their unique structural features of imidazolinone derivatives have a wide range of significant pharmacological or biological activities. The pharmaceutical companies frequently perform research and exploit their derivatives for drug discovery. In this work, we examined the progress and structural modification of 5-imidazolinone derivatives in the search for effective anticancer agents; these compounds could be promising anticancer agents with better therapeutic potential for the suppression of tumors. However, 5-imidazolinone derivatives showed anti-bacterial, anti-fungal, anti-diabetic, anti-inflammatory and analgesic activities and also exhibited better in silico and in vitro studies respectively. The specified data may be beneficial for future contrivance.
引用
收藏
页码:167 / 179
页数:13
相关论文
共 50 条
  • [1] 5-Imidazolinone Derivatives as a Potent Pharmacological Agents—A Review
    B. Sivakumar
    K. Ilango
    Russian Journal of Bioorganic Chemistry, 2023, 49 : 167 - 179
  • [2] Syntheses and QSAR studies of 5-imidazolinone derivatives as potential antibacterial agents
    Shah, MD
    Desai, NC
    Awasthi, KK
    Saxena, AK
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2001, 40 (03): : 201 - 208
  • [3] Synthesis and Antimicrobial Activity of 5-Imidazolinone Derivatives
    Desai, N. C.
    Bhavsar, A. M.
    Baldaniya, B. B.
    INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 71 (01) : 90 - 94
  • [4] Coumarin derivatives as antifungal agents-A review
    Loncar, Mirjana
    Gaso-Sokac, Dajana
    Molnar, Maja
    CZECH JOURNAL OF FOOD SCIENCES, 2023, 41 (02) : 79 - 91
  • [5] Cinnamic Acid Derivatives as Anticancer Agents-A Review
    De, P.
    Baltas, M.
    Bedos-Belval, F.
    CURRENT MEDICINAL CHEMISTRY, 2011, 18 (11) : 1672 - 1703
  • [6] Synthesis and pharmacological studies of some imidazolinone derivatives
    Kalluraya, B
    Isloor, AM
    Rao, M
    Shetty, DP
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2001, 11 (02) : 155 - 158
  • [7] Recent advances in the synthesis of pyrazoline derivatives from chalcones as potent pharmacological agents: A comprehensive review
    Yadav, Chandra Shekhar
    Azad, Iqbal
    Khan, Abdul Rahman
    Nasibullah, Malik
    Ahmad, Naseem
    Hansda, Dhananjoy
    Ali, Saud Nusrat
    Shrivastav, Kajal
    Akil, Mohd
    Lohani, Minaxi B.
    RESULTS IN CHEMISTRY, 2024, 7
  • [8] Synthesis and pharmacological evaluation of acylhydroquinone derivatives as potent antiplatelet agents
    Mendez, Diego
    Donoso-Bustamante, Viviana
    Pablo Millas-Vargas, Juan
    Pessoa-Mahana, Hernan
    Araya-Maturana, Ramiro
    Fuentes, Eduardo
    BIOCHEMICAL PHARMACOLOGY, 2021, 183
  • [9] Modeling Feedback in Interaction With Conversational Agents-A Review
    Axelsson, Agnes
    Buschmeier, Hendrik
    Skantze, Gabriel
    FRONTIERS IN COMPUTER SCIENCE, 2022, 4
  • [10] Early pharmacological profiling of isatin derivatives as potent and selective cytotoxic agents
    Puerta, Adrian
    Gonzalez-Bakker, Aday
    Brandao, Pedro
    Pineiro, Marta
    Burke, Anthony J.
    Giovannetti, Elisa
    Fernandes, Miguel X.
    Padron, Jose M.
    BIOCHEMICAL PHARMACOLOGY, 2024, 222