Glochodpurnoid B from Glochidion puberum Induces Endoplasmic Reticulum Stress-Mediated Apoptosis in Colorectal Cancer Cells

被引：2

作者：

Tian, Yang ^{[1
]}

Fan, Runzhu ^{[1
]}

Yin, Zhao ^{[2
]}

Huang, Yongping ^{[3
]}

Huang, Dong ^{[1
]}

Yuan, Fangyu ^{[1
]}

Yin, Aiping ^{[4
]}

Tang, Guihua ^{[1
]}

Pu, Rong ^{[4
]}

Yin, Sheng ^{[1
]}

机构：

[1] Sun Yat sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China

[2] Yunnan Univ, Affiliated Hosp, Peoples Hosp Yunnan Prov 2, Dept Geratol, Kunming 650021, Peoples R China

[3] Hanshan Normal Univ, Sch Life Sci & Food Engn, Chaozhou 521041, Peoples R China

[4] Third Peoples Hosp Dongguan, Dept Clin Lab, Dongguan 523326, Peoples R China

来源：

MOLECULES | 2023年 / 28卷 / 02期

关键词：

Glochidion puberum; triterpenoid; structural elucidation; apoptosis; endoplasmic reticulum stress; LUPANE-TYPE TRITERPENES; NITRIC-OXIDE; INHIBITORS;

D O I：

10.3390/molecules28020511

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glochidpurnoids A and B (1 and 2), two new coumaroyl or feruloyl oleananes, along with 17 known triterpenoids (3-19) were obtained from the stems and twigs of Glochidion puberum. Their structures were elucidated by extensive spectroscopic data analyses, chemical methods, and single crystal X-ray diffraction. All compounds were screened for cytotoxicity against the colorectal cancer cell line HCT-116, and 2, 3, 5, 6, 11, and 17 showed remarkable inhibitory activities (IC50: 0.80-2.99 mu M), being more active than the positive control 5-fluorouracil (5-FU). The mechanistic study of 2, the most potent compound, showed that it could induce endoplasmic reticulum (ER) stress-mediated apoptosis and improve the sensitivity of HCT-116 cells to 5-FU.

引用

页数：11

共 50 条

[1] Relocating NSAIDs into the endoplasmic reticulum induces ER stress-mediated apoptosis in cancer cells
Mishra, Tripti
Ingle, Jaypalsing
Saha, Aditi
Basu, Sudipta
RSC MEDICINAL CHEMISTRY, 2025,
[2] Honokiol induces endoplasmic reticulum stress-mediated apoptosis in human lung cancer cells
Zhu, Jianfei
Xu, Shuonan
Gao, Wenli
Feng, Jianyu
Zhao, Guolong
LIFE SCIENCES, 2019, 221 : 204 - 211
[3] Tannic Acid Induces Endoplasmic Reticulum Stress-Mediated Apoptosis in Prostate Cancer
Nagesh, Prashanth K. B.
Hatami, Elham
Chowdhury, Pallabita
Kashyap, Vivek K.
Khan, Sheema
Hafeez, Bilal B.
Chauhan, Subhash C.
Jaggi, Meena
Yallapu, Murali M.
CANCERS, 2018, 10 (03)
[4] Buforin IIb induces endoplasmic reticulum stress-mediated apoptosis in HeLa cells
Jang, Ju Hye
Kim, Yu Jin
Kim, Hyun
Kim, Sun Chang
Cho, Ju Hyun
PEPTIDES, 2015, 69 : 144 - 149
[5] α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells
Monica Pibiri
Pia Sulas
Tania Camboni
Vera Piera Leoni
Gabriella Simbula
Scientific Reports, 10
[6] α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells
Pibiri, Monica
Sulas, Pia
Camboni, Tania
Leoni, Vera Piera
Simbula, Gabriella
SCIENTIFIC REPORTS, 2020, 10 (01)
[7] Endoplasmic reticulum stress-mediated apoptosis in pancreatic β-cells
S. Oyadomari
E. Araki
M. Mori
Apoptosis, 2002, 7 : 335 - 345
[8] Endoplasmic reticulum stress-mediated apoptosis in pancreatic β-cells
Oyadomari, S
Araki, E
Mori, M
APOPTOSIS, 2002, 7 (04) : 335 - 345
[9] Teglicar Induces Apoptosis in HeLa Cervical Cancer Cells via Endoplasmic Reticulum Stress-Mediated Pathway
Rui Zhang
Dunli Nie
Yan Chen
Yunlan Zeng
Yu Huang
Ning Xiao
Iranian Journal of Science and Technology, Transactions A: Science, 2020, 44 : 973 - 979
[10] Teglicar Induces Apoptosis in HeLa Cervical Cancer Cells via Endoplasmic Reticulum Stress-Mediated Pathway
Zhang, Rui
Nie, Dunli
Chen, Yan
Zeng, Yunlan
Huang, Yu
Xiao, Ning
IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A-SCIENCE, 2020, 44 (04): : 973 - 979

← 1 2 3 4 5 →