Nanofiber/hydrogel composite scaffold incorporated by silicon nanoparticles for sustained delivery of osteogenic factor: in vitro study

被引：3
|
作者：
Oustadi, Fereshteh [1 ]
Imani, Rana [1 ]
Nazarpak, Masoumeh Haghbin [2 ]
Sharifi, Ali Mohammad [3 ,4 ,5 ]
McInnes, Steven J. P. [6 ]
机构：
[1] Amirkabir Univ Technol, Dept Biomed Engn, Tehran Polytech, Tehran, Iran
[2] Amirkabir Univ Technol, New Technol Res Ctr, Tehran Polytech, Tehran, Iran
[3] Iran Univ Med Sci, Stem Cell & Regenerat Med Res Ctr, Tehran, Iran
[4] Iran Univ Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran
[5] Univ Malaya, Fac Med, Dept Orthoped Surg, Tissue Engn Grp NOCERAL, Kuala Lumpur, Malaysia
[6] Univ South Australia, UniSA STEM, Mawson Lakes Campus, Mawson Lakes, SA, Australia
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2024年 / 73卷 / 03期
关键词：
Bone scaffold; drug delivery; hydrogel; nanofiber; rosuvastatin; silicon nanoparticles; POROUS SILICON; BONE-FORMATION; DRUG-RELEASE; ELECTROSPUN NANOFIBERS; STEM-CELLS; ROSUVASTATIN; GELATIN; SIMVASTATIN; GENIPIN; DIFFERENTIATION;
D O I：
10.1080/00914037.2022.2147176
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Utilizing bone scaffolds for osteogenic factors delivery has the vital advantage of faster and more efficient tissue regeneration. In this study, rosuvastatin calcium is loaded into the silicon nanoparticles and then incorporated into PLLA nanofibers followed by immersion into the gelatin hydrogel. The fabricated composites are characterized, and a drug release study shows that the nanofibers are the main barrier to drug release and provide sustained release for 21 days. Double encapsulation in the genipin-crosslinked gelatin hydrogel prolonged release to 32 days. The scaffold material shows great potential to provide a sustainable osteogenic factor delivery system.
引用
收藏
页码：200 / 213
页数：14
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