Challenges, limitations, and pitfalls of PET and advanced MRI in patients with brain tumors: A report of the PET/RANO group

被引：9

作者：

Galldiks, Norbert ^{[1
,2
,3
,4
,5
]}

Kaufmann, Timothy J. ^{[6
]}

Vollmuth, Philipp ^{[7
,11
]}

Lohmann, Philipp ^{[4
]}

Smits, Marion ^{[8
,9
]}

Veronesi, Michael C. ^{[10
]}

Langen, Karl-Josef ^{[4
,5
,11
]}

Ruda, Roberta ^{[12
]}

Albert, Nathalie L. ^{[13
]}

Hattingen, Elke ^{[14
]}

Law, Ian ^{[15
]}

Hutterer, Markus ^{[16
]}

Soffietti, Riccardo ^{[12
]}

Vogelbaum, Michael A. ^{[17
]}

Wen, Patrick Y. ^{[18
]}

Weller, Michael ^{[19
,20
,21
]}

Tonn, Joerg-Christian ^{[13
,22
]}

机构：

[1] Res Ctr Juelich, Inst Neurosci & Med INM 3, Leo Brandt Str 5, D-52425 Julich, Germany

[2] Univ Cologne, Fac Med, Dept Neurol, Cologne, Germany

[3] Univ Cologne, Univ Hosp Cologne, Cologne, Germany

[4] Res Ctr Juelich, Inst Neurosci & Med INM INM 3 4, Julich, Germany

[5] Ctr Integrated Oncol Aachen Bonn Cologne Duesseldo, Cologne, Germany

[6] Mayo Clin, Dept Radiol, Rochester, MN USA

[7] Univ Hosp Heidelberg, Dept Neuroradiol, Heidelberg, Germany

[8] Erasmus MC, Dept Radiol, Rotterdam, Netherlands

[9] Erasmus MC, Nucl Med & Brain Tumour Ctr, Rotterdam, Netherlands

[10] Univ Wisconsin, Dept Radiol, Madison, WI USA

[11] Univ Hosp RWTH Aachen, Dept Nucl Med, Aachen, Germany

[12] Univ Turin, Dept Neurosci, Div Neurooncol, Turin, Italy

[13] Ludwig Maximilians Univ Munchen, LMU Hosp, Dept Nucl Med, Munich, Germany

[14] Goethe Univ, Univ Hosp Frankfurt, Dept Neuroradiol, Frankfurt, Germany

[15] Copenhagen Univ Hosp, Dept Clin Physiol & Nucl Med, Rigshosp, Copenhagen, Denmark

[16] St John God Hosp, Dept Neurol Acute Geriatr, Linz, Austria

[17] Moffit Canc Ctr, Dept Neurooncol & Neurosurg, Tampa, FL USA

[18] Dana Farber Canc Inst, Ctr Neurooncol, Boston, MA USA

[19] Clin Neurosci Ctr, Dept Neurol, Zurich, Switzerland

[20] Univ Hosp Zurich, Zurich, Switzerland

[21] Univ Zurich, Zurich, Switzerland

[22] Univ Hosp Munich LMU, Dept Neurosurg, Munich, Germany

来源：

NEURO-ONCOLOGY | 2024年 / 26卷 / 07期

关键词：

amino acid PET; CEST; diffusion-weighted imaging; MR spectroscopy; perfusion-weighted imaging; POSITRON-EMISSION-TOMOGRAPHY; AMINO-ACID PET; MAGNETIC-RESONANCE-SPECTROSCOPY; CONSENSUS RECOMMENDATIONS; O-(2-F-18-FLUOROETHYL)-L-TYROSINE PET; CARBON-11-METHIONINE PET; FLUORINE-18-FDG PET; RESPONSE ASSESSMENT; CORTICAL DYSPLASIA; MALIGNANT GLIOMAS;

D O I：

10.1093/neuonc/noae049

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Brain tumor diagnostics have significantly evolved with the use of positron emission tomography (PET) and advanced magnetic resonance imaging (MRI) techniques. In addition to anatomical MRI, these modalities may provide valuable information for several clinical applications such as differential diagnosis, delineation of tumor extent, prognostication, differentiation between tumor relapse and treatment-related changes, and the evaluation of response to anticancer therapy. In particular, joint recommendations of the Response Assessment in Neuro-Oncology (RANO) Group, the European Association of Neuro-oncology, and major European and American Nuclear Medicine societies highlighted that the additional clinical value of radiolabeled amino acids compared to anatomical MRI alone is outstanding and that its widespread clinical use should be supported. For advanced MRI and its steadily increasing use in clinical practice, the Standardization Subcommittee of the Jumpstarting Brain Tumor Drug Development Coalition provided more recently an updated acquisition protocol for the widely used dynamic susceptibility contrast perfusion MRI. Besides amino acid PET and perfusion MRI, other PET tracers and advanced MRI techniques (e.g. MR spectroscopy) are of considerable clinical interest and are increasingly integrated into everyday clinical practice. Nevertheless, these modalities have shortcomings which should be considered in clinical routine. This comprehensive review provides an overview of potential challenges, limitations, and pitfalls associated with PET imaging and advanced MRI techniques in patients with gliomas or brain metastases. Despite these issues, PET imaging and advanced MRI techniques continue to play an indispensable role in brain tumor management. Acknowledging and mitigating these challenges through interdisciplinary collaboration, standardized protocols, and continuous innovation will further enhance the utility of these modalities in guiding optimal patient care.

引用

页码：1181 / 1194

页数：14

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