Prognostic Value of Neutrophil-to-lymphocyte Ratio for Patients with Acute Coronary Syndrome and Obstructive Sleep Apnea

被引:0
|
作者
Zhen, Lei [1 ,2 ,3 ]
Chen, Xiuhuan [1 ,2 ,3 ]
Fan, Jingyao [1 ,2 ,3 ]
Wang, Xiao [1 ,2 ,3 ]
Ai, Hui [1 ,2 ,3 ]
Que, Bin [1 ,2 ,3 ]
Gong, Wei [1 ,2 ,3 ,4 ]
Nie, Shaoping [1 ,2 ,3 ,4 ]
机构
[1] Capital Med Univ, Beijing Anzhen Hosp, Div Cardiol, Ctr Coronary Artery Dis, Beijing, Peoples R China
[2] Natl Clin Res Ctr Cardiovasc Dis, Beijing, Peoples R China
[3] Beijing Inst Heart Lung & Blood Vessel Dis, Beijing, Peoples R China
[4] Capital Med Univ, Beijing Anzhen Hosp, Ctr Coronary Artery Dis, Div Cardiol, 2 Anzhen Rd, Beijing 100029, Peoples R China
基金
中国国家自然科学基金;
关键词
neutrophil-to-lymphocyte ratio; acute coronary syndrome; obstructive sleep apnea; major adverse cardiovascular events; ASSOCIATION; SEVERITY; GUIDELINE; MORTALITY; DISEASE;
D O I
10.15212/CVIA.2024.0016
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: This study was aimed at investigating the effects of the neutrophil-to-lymphocyte ratio (NLR) on the longterm prognosis of patients with acute coronary syndrome (ACS) and obstructive sleep apnea (OSA). Methods: This prospective study enrolled patients with ACS and OSA at Anzhen Hospital between June 2015 and January 2020. OSA was defined by an apnea-hypopnea index >= 15 events center dot h(-1). Baseline NLR was classified as high or low, according to the median. The primary endpoint was major adverse cardiovascular events (MACE), comprising cardiovascular death, recurrent myocardial infarction, stroke, and ischemia-driven revascularization. Results: A total of 1011 patients with ACS and OSA were enrolled, 506 of whom were in the high NLR (>= 2.54) group. No significant differences in sleep monitoring indicators were observed. During a median follow-up of 2.8 (1.4, 3.6) years, a non -linear correlation between NLR and the incident risk of MACE was observed. After adjustment for clinically relevant confounders, a high NLR was independently associated with elevated MACE risk (adjusted HR = 1.45, 95% CI: 1.02-2.06, P = 0.040). Conclusions: In patients with ACS and OSA, a high NLR was associated with poorer clinical outcomes during longterm follow-up.
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页数:11
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