Imaging Biomarkers of Osteoarthritis

被引：4

作者：

Roemer, Frank W. ^{[1
,2
,3
]}

Wirth, Wolfgang ^{[4
,5
,6
]}

Demehri, Shadpour ^{[7
]}

Kijowski, Richard ^{[8
]}

Jarraya, Mohamed ^{[9
]}

Hayashi, Daichi ^{[10
,11
]}

Eckstein, Felix ^{[4
,5
,6
]}

Guermazi, Ali ^{[12
]}

机构：

[1] Boston Univ, Chobanian & Avedisian Sch Med, Dept Radiol, Boston, MA USA

[2] Univ Klinikum Erlangen, Dept Radiol, Maximilianspl 3, D-91054 Erlangen, Germany

[3] Friedrich Alexander Univ FAU Erlangen Nurnberg, Maximilianspl 3, D-91054 Erlangen, Germany

[4] Paracelsus Med Univ, Ctr Anat, Salzburg, Austria

[5] Paracelsus Med Univ, Ludwig Boltzmann Inst Arthrit & Rehabil LBIAR, Salzburg, Austria

[6] Chondrometrics GmbH, Freilassing, Germany

[7] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD USA

[8] NYU, Grossmann Sch Med, Dept Radiol, New York, NY USA

[9] Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Boston, MA USA

[10] Tufts Univ, Sch Med, Tufts Med Ctr, Dept Radiol, Boston, MA USA

[11] Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA USA

[12] Boston VA Healthcare Syst, Dept Radiol, West Roxbury, MA USA

来源：

SEMINARS IN MUSCULOSKELETAL RADIOLOGY | 2024年 / 28卷 / 01期

关键词：

osteoarthritis; biomarker; magnetic resonance imaging; radiography; computed tomography; JOINT-SPACE WIDTH; INDIVIDUAL RADIOGRAPHIC FEATURES; CARTILAGE THICKNESS CHANGE; MEDIAL MENISCAL EXTRUSION; MARROW LESION ASSESSMENT; KNEE OSTEOARTHRITIS; ARTICULAR-CARTILAGE; SCORING SYSTEM; INTRAARTICULAR SPRIFERMIN; PREDICTIVE-VALIDITY;

D O I：

10.1055/s-0043-1776432

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Currently no disease-modifying osteoarthritis drug has been approved for the treatment of osteoarthritis (OA) that can reverse, hold, or slow the progression of structural damage of OA-affected joints. The reasons for failure are manifold and include the heterogeneity of structural disease of the OA joint at trial inclusion, and the sensitivity of biomarkers used to measure a potential treatment effect. This article discusses the role and potential of different imaging biomarkers in OA research. We review the current role of radiography, as well as advances in quantitative three-dimensional morphological cartilage assessment and semiquantitative whole-organ assessment of OA. Although magnetic resonance imaging has evolved as the leading imaging method in OA research, recent developments in computed tomography are also discussed briefly. Finally, we address the experience from the Foundation for the National Institutes of Health Biomarker Consortium biomarker qualification study and the future role of artificial intelligence.

引用

页码：14 / 25

页数：12

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