Imaging Biomarkers of Osteoarthritis

被引：4
作者：
Roemer, Frank W. [1 ,2 ,3 ]
Wirth, Wolfgang [4 ,5 ,6 ]
Demehri, Shadpour [7 ]
Kijowski, Richard [8 ]
Jarraya, Mohamed [9 ]
Hayashi, Daichi [10 ,11 ]
Eckstein, Felix [4 ,5 ,6 ]
Guermazi, Ali [12 ]
机构：
[1] Boston Univ, Chobanian & Avedisian Sch Med, Dept Radiol, Boston, MA USA
[2] Univ Klinikum Erlangen, Dept Radiol, Maximilianspl 3, D-91054 Erlangen, Germany
[3] Friedrich Alexander Univ FAU Erlangen Nurnberg, Maximilianspl 3, D-91054 Erlangen, Germany
[4] Paracelsus Med Univ, Ctr Anat, Salzburg, Austria
[5] Paracelsus Med Univ, Ludwig Boltzmann Inst Arthrit & Rehabil LBIAR, Salzburg, Austria
[6] Chondrometrics GmbH, Freilassing, Germany
[7] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD USA
[8] NYU, Grossmann Sch Med, Dept Radiol, New York, NY USA
[9] Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Boston, MA USA
[10] Tufts Univ, Sch Med, Tufts Med Ctr, Dept Radiol, Boston, MA USA
[11] Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA USA
[12] Boston VA Healthcare Syst, Dept Radiol, West Roxbury, MA USA
来源：
SEMINARS IN MUSCULOSKELETAL RADIOLOGY | 2024年 / 28卷 / 01期
关键词：
osteoarthritis; biomarker; magnetic resonance imaging; radiography; computed tomography; JOINT-SPACE WIDTH; INDIVIDUAL RADIOGRAPHIC FEATURES; CARTILAGE THICKNESS CHANGE; MEDIAL MENISCAL EXTRUSION; MARROW LESION ASSESSMENT; KNEE OSTEOARTHRITIS; ARTICULAR-CARTILAGE; SCORING SYSTEM; INTRAARTICULAR SPRIFERMIN; PREDICTIVE-VALIDITY;
D O I：
10.1055/s-0043-1776432
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Currently no disease-modifying osteoarthritis drug has been approved for the treatment of osteoarthritis (OA) that can reverse, hold, or slow the progression of structural damage of OA-affected joints. The reasons for failure are manifold and include the heterogeneity of structural disease of the OA joint at trial inclusion, and the sensitivity of biomarkers used to measure a potential treatment effect. This article discusses the role and potential of different imaging biomarkers in OA research. We review the current role of radiography, as well as advances in quantitative three-dimensional morphological cartilage assessment and semiquantitative whole-organ assessment of OA. Although magnetic resonance imaging has evolved as the leading imaging method in OA research, recent developments in computed tomography are also discussed briefly. Finally, we address the experience from the Foundation for the National Institutes of Health Biomarker Consortium biomarker qualification study and the future role of artificial intelligence.
引用
收藏
页码：14 / 25
页数：12
相关论文
共 105 条
  • [41] Felson DT, 2008, J RHEUMATOL, V35, P2047
  • [42] The effects of sprifermin on symptoms and structure in a subgroup at risk of progression in the FORWARD knee osteoarthritis trial
    Guehring, Hans
    Moreau, Flavie
    Daelken, Benjamin
    Ladel, Christoph
    Guenther, Oliver
    Bihlet, Asger Reinstrup
    Wirth, Wolfgang
    Eckstein, Felix
    Hochberg, Marc
    Conaghan, Philip G.
    [J]. SEMINARS IN ARTHRITIS AND RHEUMATISM, 2021, 51 (02) : 450 - 456
  • [43] A call for screening MRI as a tool for osteoarthritis clinical trials
    Guermazi, Ali
    Roemer, Frank W. W.
    Jarraya, Mohamed
    Hayashi, Daichi
    [J]. SKELETAL RADIOLOGY, 2023, 52 (11) : 2011 - 2019
  • [44] Prevalence of abnormalities in knees detected by MRI in adults without knee osteoarthritis: population based observational study (Framingham Osteoarthritis Study)
    Guermazi, Ali
    Niu, Jingbo
    Hayashi, Daichi
    Roemer, Frank W.
    Englund, Martin
    Neogi, Tuhina
    Aliabadi, Piran
    McLennan, Christine E.
    Felson, David T.
    [J]. BRITISH MEDICAL JOURNAL, 2012, 345
  • [45] Assessment of synovitis with contrast-enhanced MRI using a whole-joint semiquantitative scoring system in people with, or at high risk of, knee osteoarthritis: the MOST study
    Guermazi, Ali
    Roemer, Frank W.
    Hayashi, Daichi
    Crema, Michel D.
    Niu, Jingbo
    Zhang, Yuqing
    Marra, Monica D.
    Katur, Avinash
    Lynch, John A.
    El-Khoury, George Y.
    Baker, Kristin
    Hughes, Laura B.
    Nevitt, Michael C.
    Felson, David T.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2011, 70 (05) : 805 - 811
  • [46] A non-invasive technique for 3-dimensional assessment of articular cartilage thickness based on MRI .2. Validation using CT arthrography
    Haubner, M
    Eckstein, F
    Schnier, M
    Losch, A
    Sittek, H
    Becker, C
    Kolem, H
    Reiser, M
    Englmeier, KH
    [J]. MAGNETIC RESONANCE IMAGING, 1997, 15 (07) : 805 - 813
  • [47] Effect of Intra-Articular Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With Osteoarthritis The FORWARD Randomized Clinical Trial
    Hochberg, Marc C.
    Guermazi, Ali
    Guehring, Hans
    Aydemir, Aida
    Wax, Stephen
    Fleuranceau-Morel, Patricia
    Bihlet, Asger Reinstrup
    Byrjalsen, Inger
    Andersen, Jeppe Ragnar
    Eckstein, Felix
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2019, 322 (14): : 1360 - 1370
  • [48] The reliability of a new scoring system for knee osteoarthritis MRI and the validity of bone marrow lesion assessment: BLOKS (Boston-Leeds Osteoarthritis Knee Score)
    Hunter, D. J.
    Lo, G. H.
    Gale, D.
    Grainger, A. J.
    Guermazi, A.
    Conaghan, P. G.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2008, 67 (02) : 206 - 211
  • [49] OARSI Clinical Trials Recommendations: Knee imaging in clinical trials in osteoarthritis
    Hunter, D. J.
    Altman, R. D.
    Cicuttini, Flavia M.
    Crema, M. D.
    Duryea, J.
    Eckstein, F.
    Guermazi, A.
    Kijowski, R.
    Link, T. M.
    Martel-Pelletier, J.
    Miller, C. G.
    Mosher, T. J.
    Ochoa-Albiztegui, R. E.
    Pelletier, J. -P.
    Peterfy, C.
    Raynauld, J. -P.
    Roemer, F. W.
    Totterman, S. M.
    Gold, G. E.
    [J]. OSTEOARTHRITIS AND CARTILAGE, 2015, 23 (05) : 698 - 715
  • [50] Evolution of semi-quantitative whole joint assessment of knee OA: MOAKS (MRI Osteoarthritis Knee Score)
    Hunter, D. J.
    Guermazi, A.
    Lo, G. H.
    Grainger, A. J.
    Conaghan, P. G.
    Boudreau, R. M.
    Roemer, F. W.
    [J]. OSTEOARTHRITIS AND CARTILAGE, 2011, 19 (08) : 990 - 1002
12345678910