The evolution of aging and lifespan

被引：15

作者：

Li, Stacy ^{[1
,2
]}

Vazquez, Juan Manuel ^{[1
]}

Sudmant, Peter H. ^{[1
,2
]}

机构：

[1] Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Ctr Computat Biol, Berkeley, CA 94720 USA

来源：

TRENDS IN GENETICS | 2023年 / 39卷 / 11期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

NAKED MOLE-RAT; PLURIPOTENT STEM-CELLS; CANCER RESISTANCE; SEX-DIFFERENCES; MUTATION-RATES; UNITED-STATES; LONGEVITY; INSIGHTS; GENERATION; SENESCENCE;

D O I：

10.1016/j.tig.2023.08.005

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aging is a nearly inescapable trait among organisms yet lifespan varies tremendously across different species and spans several orders of magnitude in vertebrates alone. This vast phenotypic diversity is driven by distinct evolutionary trajectories and tradeoffs that are reflected in patterns of diversification and constraint in organismal genomes. Age-specific impacts of selection also shape allele frequencies in populations, thus impacting disease susceptibility and environment-specific mortality risk. Further, the mutational processes that spawn this genetic diversity in both germline and somatic cells are strongly influenced by age and life history. We discuss recent advances in our understanding of the evolution of aging and lifespan at organismal, population, and cellular scales, and highlight outstanding questions that remain unanswered.

引用

页码：830 / 843

页数：14

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