Syndecan-1: A Novel Diagnostic and Therapeutic Target in Liver Diseases

被引：3
作者：
Zhang, Xiaoli [1 ,2 ]
Zhao, Yalei [1 ,2 ]
Liu, Liangru [1 ,2 ]
He, Yingli [1 ,2 ]
机构：
[1] Xi An Jiao Tong Univ, Dept Infect Dis, Affiliated Hosp 1, Xian, Peoples R China
[2] Coconstructed Natl Hlth Commiss PRC & Peoples Govt, Dept Pharm, Natl Reg Infect Dis Ctr, Xian, Peoples R China
来源：
CURRENT DRUG TARGETS | 2023年 / 24卷 / 15期
基金：
中国国家自然科学基金;
关键词：
Heparan sulfate proteoglycans; Syndecan-1; hepatocytes; myofibroblasts; liver diseases; HEPARAN-SULFATE PROTEOGLYCANS; GLYCOGEN-SYNTHASE KINASE-3; CELL-SURFACE PROTEOGLYCAN; GROWTH-FACTOR RECEPTOR; HEPATOCELLULAR-CARCINOMA; REDUCED EXPRESSION; CORE PROTEIN; SERUM-LEVELS; HELA-CELLS; ECTODOMAIN;
D O I：
10.2174/0113894501250057231102061624
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Syndecan-1 (SDC-1), known as a coreceptor of various growth factors or an integrin binding partner, regulates various cell behaviours. Under certain pathological conditions, SDC-1 is shed from the cell surface and plays a protective or pathogenic role in various diseases. In the liver, SDC-1 is highly expressed in hepatocytes, where it is localized on the basolateral surface. It is critical to the cellular and molecular functions of hepatocytes, including their attachment to hepatitis viruses. Previous studies have reported that SDC-1 may function as a novel and promising diagnostic and therapeutic marker for various liver diseases, such as drug-induced liver injury, liver fibrosis, and liver cancer. In this review, we summarize related research and highlight the mechanisms by which SDC-1 participates in the pathogenesis of liver diseases, as well as its potential diagnostic and therapeutic applications. This review is expected to lay the foundation for further therapeutic strategies to target SDC-1 in liver diseases.
引用
收藏
页码：1155 / 1165
页数：11
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