Human serum albumin binders: A piggyback ride for long-acting therapeutics

被引：17
作者：
Ullah, Aziz [1 ,2 ]
Shin, Goeun [1 ,4 ]
Lim, Sung In [1 ,3 ]
机构：
[1] Pukyong Natl Univ, Dept Chem Engn, Busan 48513, South Korea
[2] Gomal Univ, Fac Pharm, Gomal Ctr Pharmaceut Sci, Dera Ismail Khan 29050, Khyber Pakhtunk, Pakistan
[3] Marine BioResource Co Ltd, 365 Sinseon Ro, Busan 48548, South Korea
[4] Nbios Inc, 7 Jukheon Gil, Gangneung Si, Gangwon Do, South Korea
来源：
DRUG DISCOVERY TODAY | 2023年 / 28卷 / 10期
基金：
新加坡国家研究基金会;
关键词：
serum albumin; half-life extension; drug delivery; albumin-binding domain; long-acting therapeutics; STREPTOCOCCAL PROTEIN-G; SINGLE-CHAIN DIABODY; FATTY-ACID-BINDING; HALF-LIFE; HIGH-AFFINITY; PHARMACOKINETIC PROPERTIES; DOMAIN ANTIBODIES; CRYSTAL-STRUCTURE; FUSION PROTEIN; RECEPTOR;
D O I：
10.1016/j.drudis.2023.103738
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Human serum albumin (HSA) is the most abundant protein in the blood and has desirable properties as a drug carrier. One of the most promising ways to exploit HSA as a carrier is to append an albumin-binding moiety (ABM) to a drug for in situ HSA binding upon administration. Nature-and library-derived ABMs vary in size, affinity, and epitope, differentially improving the pharmacokinetics of an appended drug. In this review, we evaluate the current state of knowledge regarding various aspects of ABMs and the unique advantages of ABM-mediated drug delivery. Furthermore, we discuss how ABMs can be specifically modulated to maximize potential benefits in clinical development.
引用
收藏
页数：16
相关论文
共 123 条
  • [91] Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing
    Sarett, Samantha M.
    Werfel, Thomas A.
    Lee, Linus
    Jackson, Meredith A.
    Kilchrist, Kameron V.
    Brantley-Sieders, Dana
    Duvall, Craig L.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (32) : E6490 - E6497
  • [92] Effective GH Replacement With Once-weekly Somapacitan vs Daily GH in Children with GHD: 3-year Results From REAL 3
    Savendahl, Lars
    Battelino, Tadej
    Rasmussen, Michael Hojby
    Brod, Meryl
    Saenger, Paul
    Horikawa, Reiko
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2022, 107 (05) : 1357 - 1367
  • [93] Direct demonstration of a neonatal Fc receptor (FcRn)-driven endosomal sorting pathway for cellular recycling of albumin
    Schmidt, Esben G. W.
    Hvam, Michael L.
    Antunes, Filipa
    Cameron, Jason
    Viuff, Dorthe
    Andersen, Birgitte
    Kristensen, Nanna N.
    Howard, Kenneth A.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (32) : 13312 - 13322
  • [94] Crystal Structure of an HSA/FcRn Complex Reveals Recycling by Competitive Mimicry of HSA Ligands at a pH-Dependent Hydrophobic Interface
    Schmidt, Michael M.
    Townson, Sharon A.
    Andreucci, Amy J.
    King, Bracken M.
    Schirmer, Emily B.
    Murillo, Alec J.
    Dombrowski, Christian
    Tisdale, Alison W.
    Lowden, Patricia A.
    Masci, Allyson L.
    Kovalchin, Joseph T.
    Erbe, David V.
    Wittrup, K. Dane
    Furfine, Eric S.
    Barnes, Thomas M.
    [J]. STRUCTURE, 2013, 21 (11) : 1966 - 1978
  • [95] ALBUMIN INTERACTS SPECIFICALLY WITH A 60-KDA MICROVASCULAR ENDOTHELIAL GLYCOPROTEIN
    SCHNITZER, JE
    CARLEY, WW
    PALADE, GE
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (18) : 6773 - 6777
  • [96] A resource of high-quality and versatile nanobodies for drug delivery
    Shen, Zhuolun
    Xiang, Yufei
    Vergara, Sandra
    Chen, Apeng
    Xiao, Zhengyun
    Santiago, Ulises
    Jin, Changzhong
    Sang, Zhe
    Luo, Jiadi
    Chen, Kong
    Schneidman-Duhovny, Dina
    Camacho, Carlos
    Calero, Guillermo
    Hu, Baoli
    Shi, Yi
    [J]. ISCIENCE, 2021, 24 (09)
  • [97] Synthetic cationic antimicrobial peptides bind with their hydrophobic parts to drug site II of human serum albumin
    Sivertsen, Annfrid
    Isaksson, Johan
    Leiros, Hanna-Kirsti S.
    Svenson, Johan
    Svendsen, John-Sigurd
    Brandsdal, Bjorn Olav
    [J]. BMC STRUCTURAL BIOLOGY, 2014, 14
  • [98] SJOBRING U, 1992, INFECT IMMUN, V60, P3601
  • [99] The serum albumin-binding region of streptococcal protein G: A bacterial fusion partner with carrier-related properties
    Sjolander, A
    Nygren, PA
    Stahl, S
    Berzins, K
    Uhlen, M
    Perlmann, P
    Andersson, R
    [J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1997, 201 (01) : 115 - 123
  • [100] Albumin as a versatile platform for drug half-life extension
    Sleep, Darrell
    Cameron, Jason
    Evans, Leslie R.
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2013, 1830 (12): : 5526 - 5534
45678910111213