Development of gelatin-coated nanoliposomes loaded with β-cyclodextrin/ vitamin D3 inclusion complex for nutritional therapy

被引：21
作者：
Ebrahimi, Alireza [1 ,2 ,3 ]
Hamishehkar, Hamed [3 ]
Amjadi, Sajed [4 ]
机构：
[1] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Student Res Comm, Tabriz, Iran
[2] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Biotechnol Res Ctr, Dept Food Sci & Technol, Tabriz, Iran
[3] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran
[4] Urmia Univ, Fac Agr, Dept Food Sci & Technol, POB 57561-51818, Orumiyeh, Iran
来源：
FOOD CHEMISTRY | 2023年 / 424卷
关键词：
Surface coating; Drug-in-cyclodextrin-in-liposomes; Electrostatic interaction; In vitro release; C NANOLIPOSOMES; IN-LIPOSOMES; STABILITY; SOLUBILITY;
D O I：
10.1016/j.foodchem.2023.136346
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The aim of this study was to synthesize of beta-cyclodextrin/Vitamin D3 (beta CD/VitD3) inclusion complex and encapsulation of this complex with gelatin-coated nanoliposomes (NLPs). Fourier transform infrared spectros-copy confirmed the formation of beta CD/VitD3 inclusion complex. In the next step, different gelatin concentrations (1, 2, and 4 mg/mL) were used to surface coat the blank NLPs. The concentration of 2 mg/mL of gelatin was chosen as the optimal concentration for coating the complex-loaded NLPs by considering particle size, morphology, and zeta potential. The particle size and zeta potential of the coated complex-loaded NLPs were 117 +/- 2.55 nm and 19.8 +/- 1.25 mV, respectively. The images taken by transmission electron microscopy confirmed the formation of a biopolymer layer of gelatin around the NLPs' vesicles. The complex encapsulation efficiency inside the NLPs was 81.09%. The beta CD/VitD3 complex loaded NLPs and its coated form exhibited a controlled release profile in simulated gastrointestinal condition.
引用
收藏
页数：10
相关论文
共 48 条
  • [1] Characterization of beta-cyclodextrin inclusion complexes containing an essential oil component
    Abarca, Romina L.
    Rodriguez, Francisco J.
    Guarda, Abel
    Galotto, Maria J.
    Bruna, Julio E.
    [J]. FOOD CHEMISTRY, 2016, 196 : 968 - 975
  • [2] Cationic inulin as a new surface decoration hydrocolloid for improving the stability of liposomal nanocarriers
    Amjadi, Sajed
    Almasi, Hadi
    Hamishehkar, Hamed
    Khaledabad, Mohammad Alizadeh
    Lim, Loong-Tak
    [J]. COLLOIDS AND SURFACES B-BIOINTERFACES, 2022, 213
  • [3] Coating of betanin and carvone Co-loaded nanoliposomes with synthesized cationic inulin: A strategy for enhancing the stability and bioavailability
    Amjadi, Sajed
    Almasi, Hadi
    Hamishehkar, Hamed
    Khaledabad, Mohammad Alizadeh
    Lim, Loong-Tak
    [J]. FOOD CHEMISTRY, 2022, 373
  • [4] Nanophytosomes for enhancement of rutin efficacy in oral administration for diabetes treatment in streptozotocin-induced diabetic rats
    Amjadi, Sajed
    Shahnaz, Fatemeh
    Shokouhi, Behrooz
    Azarmi, Yadollah
    Siahi-Shadbad, Mohammadreza
    Ghanbarzadeh, Saeed
    Kouhsoltani, Maryam
    Ebrahimi, Alireza
    Hamishehkar, Hamed
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021, 610
  • [5] The health effects of vitamin D supplementation: evidence from human studies
    Bouillon, Roger
    Manousaki, Despoina
    Rosen, Cliff
    Trajanoska, Katerina
    Rivadeneira, Fernando
    Richards, J. Brent
    [J]. NATURE REVIEWS ENDOCRINOLOGY, 2022, 18 (02) : 96 - 110
  • [6] A novel multi-tiered experimental approach unfolding the mechanisms behind cyclodextrin-vitamin inclusion complexes for enhanced vitamin solubility and stability
    Braithwaite, Miles C.
    Kumar, Pradeep
    Choonara, Yahya E.
    du Toit, Lisa C.
    Tomar, Lomas K.
    Tyagi, Charu
    Pillay, Viness
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2017, 532 (01) : 90 - 104
  • [7] Charoenngam Nipith, 2019, J Clin Orthop Trauma, V10, P1082, DOI 10.1016/j.jcot.2019.07.004
  • [8] Co-encapsulation of curcumin and vitamin D3 in mixed phospholipid nanoliposomes using a continuous supercritical CO2 assisted process
    Chaves, Matheus A.
    Baldino, Lucia
    Pinho, Samantha C.
    Reverchon, Ernesto
    [J]. JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS, 2022, 132
  • [9] Unpurified soybean lecithins impact on the chemistry of proliposomes and liposome dispersions encapsulating vitamin D3
    Chaves, Matheus A.
    Pinho, Samantha C.
    [J]. FOOD BIOSCIENCE, 2020, 37
  • [10] Nanoliposomal peptides derived from Spirulina platensis protein accelerate full-thickness wound healing
    Ebrahimi, Alireza
    Farahpour, Mohammad Reza
    Amjadi, Sajed
    Mohammadi, Maryam
    Hamishehkar, Hamed
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2023, 630
12345