Clinical features of cutaneous infantile hemangioma combined with asymptomatic infantile hepatic hemangioma and efficacy of propranolol treatment

被引:0
作者
Li, Li [1 ]
Yu, Lu [1 ]
Xu, Zigang [1 ]
Wei, Li [1 ]
Zhang, Bin [1 ]
Han, Xiaofeng [1 ]
Sun, Yujuan [1 ]
Ma, Lin [1 ,2 ]
机构
[1] Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Dermatol, Beijing, Peoples R China
[2] Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Dermatol, Beijing 100045, Peoples R China
关键词
infantile hemangioma; infantile hepatic hemangioma; propranolol;
D O I
10.1111/jocd.15823
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Introduction: Infantile hepatic hemangioma (IHH) is a common liver tumor in infants and shares the same characteristics as cutaneous infantile hemangioma (IH). Propranolol is effective for symptomatic IHH. The clinical features between cutaneous IH and IHH, and treatment efficacy of IHH (smaller than 4 cm) is unclear. To evaluate the correlation of clinical features between cutaneous IH and IHH, as well as efficacy of systemic propranolol in the treatment of cutaneous IH combined with IHH. Materials and Methods: The clinical data of infants with complicated cutaneous IH combined with IHH treated with systemic propranolol (1.5 similar to 2 mg/(kg d)) from January 2011 to October 2020 were retrospectively analyzed. Results: Forty-five cases with IHH combined with complicated cutaneous IH were reviewed. Single cutaneous IH is more likely to be combined with focal IHH, cutaneous IH greater than 5, more likely to be combined with multiple IHH (Pearson = 0.546, p < 0.01). The mean age of focal and multiple IHH regression was 11.93 +/- 14.42 months and 10.20 +/- 9.15 months, respectively. Conclusions: The number of cutaneous IH were correlated with the number of IHH. There was no difference in the age of complete remission for focal and multiple IHH.
引用
收藏
页码:3369 / 3374
页数:6
相关论文
共 18 条
[11]   Impact of Screening for Hepatic Hemangiomas in Patients with Multiple Cutaneous Infantile Hemangiomas [J].
Rialon, Kristy L. ;
Murillo, Rudy ;
Fevurly, Rebecca D. ;
Kulungowski, Ann M. ;
Zurakowski, David ;
Liang, Marilyn ;
Kozakewich, Harry P. W. ;
Alomari, Ahmad I. ;
Fishman, Steven J. .
PEDIATRIC DERMATOLOGY, 2015, 32 (06) :808-812
[12]   Propranolol treatment in Kasabach-Merritt Syndrome secondary to congenital hepatic hemangioma. Clinical case [J].
Selzer Soria, Erika M. ;
Malla, Ivone .
ARCHIVOS ARGENTINOS DE PEDIATRIA, 2021, 119 (01) :E65-E69
[13]   Propranolol for infantile hepatic hemangioendothelioma: Clinical evaluation of drug efficacy and safety using a single-center patient cohort [J].
Tian, Ruicheng ;
Liang, Yu ;
Wang, Jing ;
Shan, Yuhua ;
Gao, Hongxiang ;
Zhang, Lei ;
Xie, Chenjie ;
Li, Jingjing ;
Xu, Min ;
Gu, Song .
ANNALS OF HEPATOLOGY, 2020, 19 (05) :530-534
[14]  
van Schaijik B, 2020, PEDIATR RES, V87, P3, DOI [10.1038/s41390-0537-y, 10.1038/s41390-019-0537-y]
[15]   Propranolol as First-Line Treatment for Life-Threatening Diffuse Infantile Hepatic Hemangioma: A Case Report [J].
Varrasso, Giulia ;
Schiavetti, Amalia ;
Lanciotti, Silvia ;
Sapio, Maria ;
Ferrara, Eva ;
De Grazia, Alessandra ;
Clerico, Anna .
HEPATOLOGY, 2017, 66 (01) :283-285
[16]   Clinical evaluation of transcatheter arterial embolization combined with propranolol orally treatment of infantile hepatic hemangioma [J].
Wang, Liang ;
Li, Jing ;
Song, Dan ;
Guo, Lei .
PEDIATRIC SURGERY INTERNATIONAL, 2022, 38 (08) :1149-1155
[17]   Progressive infantile hepatic hemangioma not responding to propranolol [J].
Yang, Kaiying ;
Feng, Liwei ;
Chen, Siyuan ;
Ji, Yi .
JOURNAL OF DERMATOLOGY, 2019, 46 (08) :E275-E276
[18]   Efficacy of propranolol treatment in infantile hepatic haemangioma [J].
Yang, Kaiying ;
Peng, Suhua ;
Chen, Linwen ;
Chen, Siyuan ;
Ji, Yi .
JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 2019, 55 (10) :1194-1200