The Potential of Ginkgo biloba as a Source of Biologically Active Compounds-A Review of the Recent Literature and Patents

被引:50
作者
Biernacka, Patrycja [1 ]
Adamska, Iwona [1 ]
Felisiak, Katarzyna [1 ]
机构
[1] Technol West Pomeranian Univ Technol, Fac Food Sci & Fisheries, Dept Food Sci, PL-70310 Szczecin, Poland
关键词
ginkgo biloba; patents; ginkgotoxin; pro-health properties; food industry; P-HYDROXYBENZOIC ACID; LEAF EXTRACT; ANTIOXIDANT PROPERTIES; INFLAMMATORY RESPONSE; ENDOTHELIAL-CELLS; SAFETY ASSESSMENT; CANCER; LEAVES; L; TOXICITY;
D O I
10.3390/molecules28103993
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ginkgo biloba is a relict tree species showing high resistance to adverse biotic and abiotic environmental factors. Its fruits and leaves have high medicinal value due to the presence of flavonoids, terpene trilactones and phenolic compounds. However, ginkgo seeds contain toxic and allergenic alkylphenols. The publication revises the latest research results (mainly from 2018-2022) regarding the chemical composition of extracts obtained from this plant and provides information on the use of extracts or their selected ingredients in medicine and food production. A very important section of the publication is the part in which the results of the review of patents concerning the use of Ginkgo biloba and its selected ingredients in food production are presented. Despite the constantly growing number of studies on its toxicity and interactions with synthetic drugs, its health-promoting properties are the reason for the interest of scientists and motivation to create new food products.
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页数:54
相关论文
共 233 条
[111]   Anti-tumor effect of ginkgetin on human hepatocellular carcinoma cell lines by inducing cell cycle arrest and promoting cell apoptosis [J].
Liu, Qiong ;
Chen, Lingying ;
Yin, Wenjun ;
Nie, Yuehua ;
Zeng, Penghui ;
Yang, Xin .
CELL CYCLE, 2022, 21 (01) :74-85
[112]   Ginkgo biloba extract enhances chemotherapy sensitivity and reverses chemoresistance through suppression of the KSR1-mediated ERK1/2 pathway in gastric cancer cells [J].
Liu, Shi-Quan ;
Xu, Chun-Yan ;
Qin, Meng-Bin ;
Tan, Lin ;
Zhuge, Chun-Feng ;
Mao, Ye-Bo ;
Lai, Ming-Yu ;
Huang, Jie-An .
ONCOLOGY REPORTS, 2015, 33 (06) :2871-2882
[113]   Reproductive and developmental toxicity study of caffeic acid in mice [J].
Liu, Yang ;
Qiu, Shidong ;
Wang, Lingjun ;
Zhang, Na ;
Shi, Yan ;
Zhou, Hai ;
Liu, Xinguang ;
Shao, Linlin ;
Liu, Xuena ;
Chen, Jian ;
Hou, Ming .
FOOD AND CHEMICAL TOXICOLOGY, 2019, 123 :106-112
[114]   Chlorogenic acid: A comprehensive review of the dietary sources, processing effects, bioavailability, beneficial properties, mechanisms of action, and future directions [J].
Lu, Huijie ;
Tian, Zhimei ;
Cui, Yiyan ;
Liu, Zhichang ;
Ma, Xianyong .
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY, 2020, 19 (06) :3130-3158
[115]   Bilobalide: A review of its pharmacology, pharmacokinetics, toxicity, and safety [J].
Lu, Jing ;
Xie, Long ;
Liu, Kai ;
Zhang, Xuming ;
Wang, Xian ;
Dai, Xiaolin ;
Liang, Youdan ;
Cao, Yi ;
Li, Xiaofang .
PHYTOTHERAPY RESEARCH, 2021, 35 (11) :6114-6130
[116]   Liquid profiling in plants: identification and analysis of extracellular metabolites and miRNAs in pollination drops of Ginkgo biloba [J].
Lu, Zhaogeng ;
Jiang, Bei ;
Zhao, Beibei ;
Mao, Xinyu ;
Lu, Jinkai ;
Jin, Biao ;
Wang, Li .
TREE PHYSIOLOGY, 2020, 40 (10) :1420-1436
[117]   Ginkgolide B lowers body weight and ameliorates hepatic steatosis in high-fat diet-induced obese mice correlated with pregnane X receptor activation [J].
Luo, Lingling ;
Li, Yin ;
Wang, Dongshan ;
Zhao, Yuanyuan ;
Wang, Yahui ;
Li, Fei ;
Fang, Jinan ;
Chen, Hui ;
Fan, Shengjie ;
Huang, Cheng .
RSC ADVANCES, 2017, 7 (60) :37858-37866
[118]  
Lyu Q., 2014, Manufacturing Method of Ginkgo Health-Care Wine, Patent No. [CN103773660A, 103773660]
[119]   Biological Activities Underlying the Therapeutic Effect of Quercetin on Inflammatory Bowel Disease [J].
Lyu, Yong-Li ;
Zhou, Hai-Feng ;
Yang, Jia ;
Wang, Fa-Xi ;
Sun, Fei ;
Li, Jun-Yi .
MEDIATORS OF INFLAMMATION, 2022, 2022
[120]   Transport of ginkgolides with different lipophilicities based on an hCMEC/D3 cell monolayer as a blood-brain barrier cell model [J].
Ma, Shuwei ;
Liu, Xingyan ;
Xu, Qingrun ;
Zhang, Xiantao .
LIFE SCIENCES, 2014, 114 (02) :93-101