Recent advances in the role of exosomes in liver fibrosis

被引：7

作者：

Shen, Jiliang ^{[1
]}

Cao, Jiasheng ^{[1
]}

Chen, Mingyu ^{[1
,4
]}

Zhang, Yaping ^{[2
,3
]}

机构：

[1] Sir Run Run Shaw Hosp, Dept Gen Surg, Hangzhou, Peoples R China

[2] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Anesthesiol, Hangzhou, Peoples R China

[3] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, 3 East Qing Chun Rd, Hangzhou 310016, Zhejiang, Peoples R China

[4] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gen Surg, Hangzhou 310016, Zhejiang, Peoples R China

来源：

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2023年 / 38卷 / 07期

基金：

中国国家自然科学基金;

关键词：

exosome; hepatic stellate cell; liver fibrosis; mesenchymal stem cell; microRNA; vesicle; HEPATIC STELLATE CELLS; MESENCHYMAL STEM-CELLS; AUTOPHAGY;

D O I：

10.1111/jgh.16203

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background and AimWe aim to summarize the current status of research on the role of exosomes in liver fibrosis. MethodsA review of the relevant literature was performed and the key findings were presented. ResultsMost studies focused on the role of exosomes derived from mesenchymal stem cells, other types of stem cells, and liver resident cells including hepatocytes, cholangiocytes, and hepatic stellate cells in liver fibrosis. Exosomes have been reported to play an essential role in the inactivation or activation of hepatic stellate cells through the delivery of non-coding RNAs and proteins. In recent years, this exosome cargo has become a research hotspot. ConclusionsRecent studies have indicated the potential therapeutic benefit of exosomes in liver fibrosis.

引用

页码：1083 / 1088

页数：6

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