Association of cumulative prenatal adversity with infant subcortical structure volumes and child problem behavior and its moderation by a coexpression polygenic risk score of the serotonin system

被引：3

作者：

Acosta, Henriette ^{[1
,2
]}

Kantojaervi, Katri ^{[3
,4
]}

Tuulari, Jetro J. ^{[1
,5
,6
,7
]}

Lewis, John D. ^{[8
]}

Hashempour, Niloofar ^{[1
]}

Scheinin, Noora M. ^{[1
,5
]}

Lehtola, Satu J. ^{[1
]}

Nolvi, Saara ^{[1
,9
]}

Fonov, Vladimir S. ^{[8
]}

Collins, D. Louis ^{[8
]}

Evans, Alan C. ^{[8
]}

Parkkola, Riitta ^{[10
]}

Laehdesmaeki, Tuire ^{[11
]}

Saunavaara, Jani ^{[12
]}

Merisaari, Harri ^{[1
,10
,13
]}

Karlsson, Linnea ^{[1
,14
,15
]}

Paunio, Tiina ^{[3
,4
]}

Karlsson, Hasse ^{[1
,5
,14
]}

机构：

[1] Univ Turku, Inst Clin Med, Turku Brain & Mind Ctr, FinnBrain Birth Cohort Study, Turku, Finland

[2] Philipps Univ Marburg, Dept Psychiat & Psychotherapy, Marburg, Germany

[3] Finnish Inst Hlth & Welf, Publ Hlth & Welf, Helsinki, Finland

[4] Univ Helsinki, Helsinki Univ Cent Hosp, Fac Med, Dept Psychiat, Helsinki, Finland

[5] Univ Turku, Turku Univ Hosp, Dept Psychiat, Turku, Finland

[6] Univ Turku, Turku Coll Sci & Med, Turku, Finland

[7] Univ Oxford, Dept Psychiat, Oxford, England

[8] McGill Univ, Montreal Neurol Inst, Montreal, PQ, Canada

[9] Univ Turku, Turku Inst Adv Studies, Dept Psychol & Speech Language Pathol, Turku, Finland

[10] Univ Turku, Turku Univ Hosp, Dept Radiol, Turku, Finland

[11] Univ Turku, Turku Univ Hosp, Dept Pediat Neurol, Turku, Finland

[12] Turku Univ Hosp, Dept Med Phys, Turku, Finland

[13] Univ Turku, Dept Future Technol, Turku, Finland

[14] Univ Turku, Turku Univ Hosp, Ctr Populat Hlth Res, Turku, Finland

[15] Univ Turku, Turku Univ Hosp, Dept Paediat & Adolescent Med, Turku, Finland

来源：

DEVELOPMENT AND PSYCHOPATHOLOGY | 2024年 / 36卷 / 03期

关键词：

amygdala; hyperactivity; MRI; prenatal stress; SDQ; MATERNAL DEPRESSIVE SYMPTOMS; AMYGDALA VOLUME; DIFFICULTIES QUESTIONNAIRE; TRANSPORTER GENE; PREGNANCY ANXIETY; BRAIN-DEVELOPMENT; SELF-REGULATION; MENTAL-HEALTH; STRESS; FETAL;

D O I：

10.1017/S0954579423000275

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Prenatal adversity has been linked to later psychopathology. Yet, research on cumulative prenatal adversity, as well as its interaction with offspring genotype, on brain and behavioral development is scarce. With this study, we aimed to address this gap. In Finnish mother-infant dyads, we investigated the association of a cumulative prenatal adversity sum score (PRE-AS) with (a) child emotional and behavioral problems assessed with the Strengths and Difficulties Questionnaire at 4 and 5 years (N = 1568, 45.3% female), (b) infant amygdalar and hippocampal volumes (subsample N = 122), and (c) its moderation by a hippocampal-specific coexpression polygenic risk score based on the serotonin transporter (SLC6A4) gene. We found that higher PRE-AS was linked to greater child emotional and behavioral problems at both time points, with partly stronger associations in boys than in girls. Higher PRE-AS was associated with larger bilateral infant amygdalar volumes in girls compared to boys, while no associations were found for hippocampal volumes. Further, hyperactivity/inattention in 4-year-old girls was related to both genotype and PRE-AS, the latter partially mediated by right amygdalar volumes as preliminary evidence suggests. Our study is the first to demonstrate a dose-dependent sexually dimorphic relationship between cumulative prenatal adversity and infant amygdalar volumes.

引用

页码：1027 / 1042

页数：16