High-grade B-cell lymphoma (HGBL)-NOS is clinicopathologically and genetically more similar to DLBCL/HGBL-DH than DLBCL

被引：13

作者：

Li, Shaoying ^{[1
]}

Qiu, Lianqun ^{[1
]}

Xu, Jie ^{[1
]}

Lin, Pei ^{[1
]}

Ok, Chi Young ^{[1
]}

Tang, Guilin ^{[1
]}

McDonnell, Timothy J. ^{[1
]}

James You, M. ^{[1
]}

Khanlari, Mahsa ^{[1
]}

Miranda, Roberto N. ^{[1
]}

Jeffrey Medeiros, L. ^{[1
]}

机构：

[1] UT MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USA

来源：

LEUKEMIA | 2023年 / 37卷 / 02期

关键词：

DOUBLE-HIT LYMPHOMA; RITUXIMAB PLUS CYCLOPHOSPHAMIDE; MYC; CLASSIFICATION; IMMUNOPHENOTYPE; VINCRISTINE; DOXORUBICIN; EXPRESSION; NEOPLASMS; OUTCOMES;

D O I：

10.1038/s41375-022-01778-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

High-grade B-cell lymphoma, not otherwise specified (HGBL-NOS) is rare and data focused on these neoplasms is lacking. We studied the clinicopathologic and genetic features of 136 HGBL-NOS patients and compared them to patients with DLBCL/HGBL-DH (n = 224, defined by 5th Edition WHO) and DLBCL (n = 217). HGBL-NOS patients had clinical features similar to DLBCL/HGBL-DH patients. MYC rearrangement (MYC-R) was present in 43% of HGBL-NOS. With induction regimen similar to DLBCL/HGBL-DH patients, HGBL-NOS patients had a median overall survival (OS) of 28.9 months, similar to DLBCL/HGBL-DH (p = 0.48) but inferior to DLBCL patients (p = 0.03). R-EPOCH induction was associated with improved OS compared with R-CHOP. MYC-R, history of lymphoma, and high IPI were independent adverse prognostic factors in HGBL-NOS patients. Whole transcriptome profiling performed on a subset of HGBL-NOS cases showed a profile more similar to DLBCL/HGBL-DH than to DLBCL; 53% of HGBL-NOS had a DH-like signature (DH-like-Sig) and were enriched for MYC-R. DH-like-Sig+ HGBL-NOS patients had a poorer OS than DH-like-Sig-negative patients (p = 0.04). In conclusion, HGBL-NOS has clinicopathologic features and a gene expression profile more similar to DLBCL/HGBL-DH than to DLBCL. Cases of HGBL-NOS frequently carry MYC-R and have a DH-like-Sig+. R-EPOCH induction in HGBL-NOS appears associated with improved OS compared with standard R-CHOP.

引用

页码：422 / 432

页数：11

共 42 条

[1] The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms [J].

Alaggio, Rita ;

Amador, Catalina ;

Anagnostopoulos, Ioannis ;

Attygalle, Ayoma D. ;

Araujo, Iguaracyra Barreto de Oliveira ;

Berti, Emilio ;

Bhagat, Govind ;

Borges, Anita Maria ;

Boyer, Daniel ;

Calaminici, Mariarita ;

Chadburn, Amy ;

Chan, John K. C. ;

Cheuk, Wah ;

Chng, Wee-Joo ;

Choi, John K. ;

Chuang, Shih-Sung ;

Coupland, Sarah E. ;

Czader, Magdalena ;

Dave, Sandeep S. ;

de Jong, Daphne ;

Du, Ming-Qing ;

Elenitoba-Johnson, Kojo S. ;

Ferry, Judith ;

Geyer, Julia ;

Gratzinger, Dita ;

Guitart, Joan ;

Gujral, Sumeet ;

Harris, Marian ;

Harrison, Christine J. ;

Hartmann, Sylvia ;

Hochhaus, Andreas ;

Jansen, Patty M. ;

Karube, Kennosuke ;

Kempf, Werner ;

Khoury, Joseph ;

Kimura, Hiroshi ;

Klapper, Wolfram ;

Kovach, Alexandra E. ;

Kumar, Shaji ;

Lazar, Alexander J. ;

Lazzi, Stefano ;

Leoncini, Lorenzo ;

Leung, Nelson ;

Leventaki, Vasiliki ;

Li, Xiao-Qiu ;

Lim, Megan S. ;

Liu, Wei-Ping ;

Louissaint, Abner, Jr. ;

Marcogliese, Andrea ;

Medeiros, L. Jeffrey .

LEUKEMIA, 2022, 36 (07) :1720-1748

[2] Biological characterization of adult MYC-translocation-positive mature B-cell lymphomas other than molecular Burkitt lymphoma [J].

Aukema, Sietse M. ;

Kreuz, Markus ;

Kohler, Christian W. ;

Rosolowski, Maciej ;

Hasenclever, Dirk ;

Hummel, Michael ;

Kueppers, Ralf ;

Lenze, Dido ;

Ott, German ;

Pott, Christiane ;

Richter, Julia ;

Rosenwald, Andreas ;

Szczepanowski, Monika ;

Schwaenen, Carsten ;

Stein, Harald ;

Trautmann, Heiko ;

Wessendorf, Swen ;

Truemper, Lorenz ;

Loeffler, Markus ;

Spang, Rainer ;

Kluin, Philip M. ;

Klapper, Wolfram ;

Siebert, Reiner .

HAEMATOLOGICA, 2014, 99 (04) :726-735

[3] Mutational Landscape of TdT+ Large B-cell Lymphomas Supports Their Distinction From B-lymphoblastic Neoplasms A Multiparameter Study of a Rare and Aggressive Entity [J].

Bhavsar, Shweta ;

Liu, Yen-Chun ;

Gibson, Sarah E. ;

Moore, Erika M. ;

Swerdlow, Steven H. .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2022, 46 (01) :71-82

[4] The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee [J].

Campo, Elias ;

Jaffe, Elaine S. ;

Cook, James R. ;

Quintanilla-Martinez, Leticia ;

Swerdlow, Steven H. ;

Anderson, Kenneth C. ;

Brousset, Pierre ;

Cerroni, Lorenzo ;

de Leval, Laurence ;

Dirnhofer, Stefan ;

Dogan, Ahmet ;

Feldman, Andrew L. ;

Fend, Falko ;

Friedberg, Jonathan W. ;

Gaulard, Philippe ;

Ghia, Paolo ;

Horwitz, Steven M. ;

King, Rebecca L. ;

Salles, Gilles ;

San-Miguel, Jesus ;

Seymour, John F. ;

Treon, Steven P. ;

Vose, Julie M. ;

Zucca, Emanuele ;

Advani, Ranjana ;

Ansell, Stephen ;

Au, Wing-Yan ;

Barrionuevo, Carlos ;

Bergsagel, Leif ;

Chan, Wing C. ;

Cohen, Jeffrey I. ;

d'Amore, Francesco ;

Davies, Andrew ;

Falini, Brunangelo ;

Ghobrial, Irene M. ;

Goodlad, John R. ;

Gribben, John G. ;

Hsi, Eric D. ;

Kahl, Brad S. ;

Kim, Won-Seog ;

Kumar, Shaji ;

LaCasce, Ann S. ;

Laurent, Camille ;

Lenz, Georg ;

Leonard, John P. ;

Link, Michael P. ;

Lopez-Guillermo, Armando ;

Mateos, Maria Victoria ;

Macintyre, Elizabeth ;

Melnick, Ari M. .

BLOOD, 2022, 140 (11) :1229-1253

[5]

Collinge BJ., 2021, Hematol Oncol, V39, P157

[6] Double-Hit Gene Expression Signature Defines a Distinct Subgroup of Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma [J].

Ennishi, Daisuke ;

Jiang, Aixiang ;

Boyle, Merrill ;

Collinge, Brett ;

Grande, Bruno M. ;

Ben-Neriah, Susana ;

Rushton, Christopher ;

Tang, Jeffrey ;

Thomas, Nicole ;

Slack, Graham W. ;

Farinha, Pedro ;

Takata, Katsuyoshi ;

Miyata-Takata, Tomoko ;

Craig, Jeffrey ;

Mottok, Anja ;

Meissner, Barbara ;

Saberi, Saeed ;

Bashashati, Ali ;

Villa, Diego ;

Savage, Kerry J. ;

Sehn, Laurie H. ;

Kridel, Robert ;

Mungall, Andrew J. ;

Marra, Marco A. ;

Shah, Sohrab P. ;

Steidl, Christian ;

Connors, Joseph M. ;

Gascoyne, Randy D. ;

Morin, Ryan D. ;

Scott, David W. .

JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (03) :190-+

[7] Targeted next generation sequencing reveals high mutation frequency of CREBBP, BCL2 and KMT2D in high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements [J].

Evrard, Solene M. ;

Pericart, Sarah ;

Grand, David ;

Amara, Nadia ;

Escudie, Frederic ;

Gilhodes, Julia ;

Bories, Pierre ;

Traverse-Glehen, Alexandra ;

Dubois, Romain ;

Brousset, Pierre ;

Parrens, Marie ;

Laurent, Camille .

HAEMATOLOGICA, 2019, 104 (04) :E154-E157

[8] Comparison of Reproducibility, Accuracy, Sensitivity, and Specificity of miRNA Quantification Platforms [J].

Godoy, Paula M. ;

Barczak, Andrea J. ;

DeHoff, Peter ;

Srinivasan, Srimeenakshi ;

Etheridge, Alton ;

Galas, David ;

Das, Saumya ;

Erle, David J. ;

Laurent, Louise C. .

CELL REPORTS, 2019, 29 (12) :4212-+

[9] BCL2 translocation in high grade B cell lymphoma (NOS, DH/TH) is associated with reduced progression free survival [J].

Gonzalez de Villambrosia, Sonia ;

Bastos, Mariana ;

Menarguez Palanca, Javier ;

Gayoso Cruz, Jorge ;

Navarro, Jose-Tomas ;

Tapia, Gustavo ;

Alvarez Alonso, Sara ;

Martin, Alejandro ;

Blanco, Oscar ;

Abrisqueta, Pau ;

Castellvi, Josep ;

Garcia-Noblejas, Ana ;

Arranz, Reyes ;

Adrados, Magdalena ;

Lopez, Andres ;

Montes-Moreno, Santiago .

LEUKEMIA & LYMPHOMA, 2022, 63 (01) :101-108

[10] Immunohistochemical Double-Hit Score Is a Strong Predictor of Outcome in Patients With Diffuse Large B-Cell Lymphoma Treated With Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone [J].

Green, Tina Marie ;

Young, Ken H. ;

Visco, Carlo ;

Xu-Monette, Zijun Y. ;

Orazi, Attilio ;

Go, Ronald S. ;

Nielsen, Ole ;

Gadeberg, Ole V. ;

Mourits-Andersen, Torben ;

Frederiksen, Mikael ;

Pedersen, Lars Moller ;

Moller, Michael Boe .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (28) :3460-3467

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