Copper- and Visible-Light-Catalyzed Cascade Radical Cyclization of N-Propargylindoles with Cyclic Ethers

被引：13

作者：

Wang, Luyao ^{[1
]}

Li, Mengting ^{[1
]}

Ning, Zhitao ^{[1
]}

Zhang, Xi ^{[1
]}

Fu, Ying ^{[1
]}

Du, Zhengyin ^{[1
]}

机构：

[1] Northwest Normal Univ, Minist Educ, Coll Chem & Chem Engn, Key Lab Eco Funct Polymer Mat, Lanzhou 730070, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 10期

基金：

中国国家自然科学基金;

关键词：

3-COMPONENT REACTION; CYCLOADDITION; ARYLATION; PROGRESS;

D O I：

10.1021/acs.joc.2c01713

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient visible-light-assisted, copper-catalyzed tandem radical cyclization of N-propargylindoles with cyclic ethers is established. A series of 2-oxoalkyl-9H-pyrrolo[1,2-a]indol-9-ones with potential biological activities were synthesized in moderate yields by using a dual catalytic system with copper acetate as a transition metal catalyst and eosin Y as a visible light catalyst. The investigation of reaction mechanism shows that it goes through a cascade oxoalkyl radical addition, cyclization, and oxidation process.

引用

页码：6374 / 6381

页数：8

共 40 条

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