Copper- and Visible-Light-Catalyzed Cascade Radical Cyclization of N-Propargylindoles with Cyclic Ethers

被引:13
作者
Wang, Luyao [1 ]
Li, Mengting [1 ]
Ning, Zhitao [1 ]
Zhang, Xi [1 ]
Fu, Ying [1 ]
Du, Zhengyin [1 ]
机构
[1] Northwest Normal Univ, Minist Educ, Coll Chem & Chem Engn, Key Lab Eco Funct Polymer Mat, Lanzhou 730070, Peoples R China
基金
中国国家自然科学基金;
关键词
3-COMPONENT REACTION; CYCLOADDITION; ARYLATION; PROGRESS;
D O I
10.1021/acs.joc.2c01713
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An efficient visible-light-assisted, copper-catalyzed tandem radical cyclization of N-propargylindoles with cyclic ethers is established. A series of 2-oxoalkyl-9H-pyrrolo[1,2-a]indol-9-ones with potential biological activities were synthesized in moderate yields by using a dual catalytic system with copper acetate as a transition metal catalyst and eosin Y as a visible light catalyst. The investigation of reaction mechanism shows that it goes through a cascade oxoalkyl radical addition, cyclization, and oxidation process.
引用
收藏
页码:6374 / 6381
页数:8
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