Ibuprofen nanoparticles-loaded sodium alginate/psyllium seed mucilage beads: evaluation the effect of different parameters on release and swelling rate

Drug delivery systems (DDS) using polymer carriers have been received considerable attention due to their very small diameter, slow drug release, loading high doses of drugs, and preventing drug degradation. In this study, ibuprofen nanoparticles (Ibp NPs) with a particle size of less than 50 nm were synthesized and loaded into sodium alginate/psyllium seed mucilage (SA/PSM) carriers for a controlled drug release. FTIR results confirmed the presence of PSM and Ibp NPs in the SA beads. Furthermore, SEM images showed the formation of beads with porous and interconnected structures. Swelling and release were investigated by changing the pH of the medium; accordingly, the lowest swelling and release of Ibp NPs were obtained in the acidic medium due to the hydrogen bonding between carboxylic groups in the SA. Furthermore, it was found that drug release from SA beads was Fickian diffusion mechanism type, while by adding of PSM to the SA with 1.0:0.5 and 2.0:0.5 ratio, release type was anomalous transport and case-II transport, respectively. Overall, we presented SA/PSM beads as a carrier for a controlled release of Ibp NPs, which might be interesting for biomedical applications.