Spectral and temporal detection of blood bilirubin level using a point-of-care device

被引:0
作者
Ndabakuranye, Jean Pierre [1 ]
Choy, Kay Weng [2 ]
Prawer, Steven [3 ]
Ahnood, Arman [1 ]
机构
[1] RMIT Univ, Sch Engn, Melbourne, Vic 3038, Australia
[2] Northern Hlth, Northern Pathol Victoria, Epping, Vic 3076, Australia
[3] Univ Melbourne, Sch Phys, Melbourne, Vic 3010, Australia
来源
2023 45TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE & BIOLOGY SOCIETY, EMBC | 2023年
基金
澳大利亚研究理事会;
关键词
Biosensing; Bilirubin; Biomarker; Blood; Degradation; Point-of-Care; Translational medicine; SYSTEM;
D O I
10.1109/EMBC40787.2023.10340716
中图分类号
TP18 [人工智能理论];
学科分类号
081104 ; 0812 ; 0835 ; 1405 ;
摘要
Bilirubin is a biomarker for liver inflammation used to assess liver functions. Its concentration in the blood has been measured using a range of techniques both in clinical and point-of-care settings. Existing point-of-care devices utilize a spectral approach, namely dual-wavelength absorption measurement, to assess the blood bilirubin concentration. This work examines a novel temporal approach based on the photodegradation of bilirubin in the blood sample. It demonstrates that combining photodegradation characteristics with dual-wavelength measurement produces a more accurate technique for measuring blood bilirubin concentration. Tracking the evolution of absorbed light as a function of time represents a low-cost and simple way of improving the accuracy of point-of-care devices for bilirubin measurements.
引用
收藏
页数:4
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