Natural Polymer-Based Hydrogels: From Polymer to Biomedical Applications

被引:124
作者
Zhao, Lingling [1 ]
Zhou, Yifan [1 ]
Zhang, Jiaying [1 ,2 ]
Liang, Hongze [1 ]
Chen, Xianwu [3 ]
Tan, Hui [2 ]
机构
[1] Ningbo Univ, Sch Mat Sci & Chem Engn, Ningbo 315211, Peoples R China
[2] Shenzhen Childrens Hosp, Ctr Child Care & Mental Hlth CCCMH, Shenzhen 518038, Peoples R China
[3] Ningbo Univ, Affiliated Hosp, Med Sch, Ningbo 315211, Peoples R China
关键词
hydrogel; natural polymer; drug delivery; tissue engineering; wound healing; PARTIALLY OXIDIZED ALGINATE; CHITOSAN-BASED HYDROGELS; DRUG-DELIVERY; CROSS-LINKING; NANOCOMPOSITE HYDROGELS; MYOCARDIAL-INFARCTION; COMPOSITE HYDROGEL; HIGH-STRENGTH; CELLULOSE; GELATIN;
D O I
10.3390/pharmaceutics15102514
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Hydrogels prepared from natural polymer have attracted extensive attention in biomedical fields such as drug delivery, wound healing, and regenerative medicine due to their good biocompatibility, degradability, and flexibility. This review outlines the commonly used natural polymer in hydrogel preparation, including cellulose, chitosan, collagen/gelatin, alginate, hyaluronic acid, starch, guar gum, agarose, and dextran. The polymeric structure and process/synthesis of natural polymers are illustrated, and natural polymer-based hydrogels including the hydrogel formation and properties are elaborated. Subsequently, the biomedical applications of hydrogels based on natural polymer in drug delivery, tissue regeneration, wound healing, and other biomedical fields are summarized. Finally, the future perspectives of natural polymers and hydrogels based on them are discussed. For natural polymers, novel technologies such as enzymatic and biological methods have been developed to improve their structural properties, and the development of new natural-based polymers or natural polymer derivatives with high performance is still very important and challenging. For natural polymer-based hydrogels, novel hydrogel materials, like double-network hydrogel, multifunctional composite hydrogels, and hydrogel microrobots have been designed to meet the advanced requirements in biomedical applications, and new strategies such as dual-cross-linking, microfluidic chip, micropatterning, and 3D/4D bioprinting have been explored to fabricate advanced hydrogel materials with designed properties for biomedical applications. Overall, natural polymeric hydrogels have attracted increasing interest in biomedical applications, and the development of novel natural polymer-based materials and new strategies/methods for hydrogel fabrication are highly desirable and still challenging.
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页数:31
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共 197 条
[1]   Ecofriendly green conversion of potato peel wastes to high productivity bacterial cellulose [J].
Abdelraof, Mohamed ;
Hasanin, Mohamed S. ;
El-Saied, Houssni .
CARBOHYDRATE POLYMERS, 2019, 211 :75-83
[2]   4D printing in biomedical applications: emerging trends and technologies [J].
Agarwal, Tarun ;
Hann, Sung Yun ;
Chiesa, Irene ;
Cui, Haitao ;
Celikkin, Nehar ;
Micalizzi, Simone ;
Barbetta, Andrea ;
Costantini, Marco ;
Esworthy, Timothy ;
Zhang, Lijie Grace ;
De Maria, Carmelo ;
Maiti, Tapas Kumar .
JOURNAL OF MATERIALS CHEMISTRY B, 2021, 9 (37) :7608-7632
[3]   Designed protein- and peptide-based hydrogels for biomedical sciences [J].
Ahn, Wonkyung ;
Lee, Jong-Hwan ;
Kim, Soo Rin ;
Lee, Jeewon ;
Lee, Eun Jung .
JOURNAL OF MATERIALS CHEMISTRY B, 2021, 9 (08) :1919-1940
[4]   Biocompatible scaffolds based on natural polymers for regenerative medicine [J].
Akilbekova, Dana ;
Shaimerdenova, Madina ;
Adilov, Salimgerey ;
Berillo, Dmitriy .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 114 :324-333
[5]   RADIOIODINATION OF ALGINATE VIA COVALENTLY-BOUND TYROSINAMIDE ALLOWS MONITORING OF ITS FATE IN-VIVO [J].
ALSHAMKHANI, A ;
DUNCAN, R .
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, 1995, 10 (01) :4-13
[6]   Fast Stereolithography Printing of Large-Scale Biocompatible Hydrogel Models [J].
Anandakrishnan, Nanditha ;
Ye, Hang ;
Guo, Zipeng ;
Chen, Zhaowei ;
Mentkowski, Kyle, I ;
Lang, Jennifer K. ;
Rajabian, Nika ;
Andreadis, Stelios T. ;
Ma, Zhen ;
Spernyak, Joseph A. ;
Lovell, Jonathan F. ;
Wang, Depeng ;
Xia, Jun ;
Zhou, Chi ;
Zhao, Ruogang .
ADVANCED HEALTHCARE MATERIALS, 2021, 10 (10)
[7]   Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis [J].
Andrews, Forest H. ;
Singh, Alok R. ;
Joshi, Shweta ;
Smith, Cassandra A. ;
Morales, Guillermo A. ;
Garlich, Joseph R. ;
Durden, Donald L. ;
Kutateladze, Tatiana G. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (07) :E1072-E1080
[8]   Evaluation of the in vivo fate of ultrapure alginate in a BALB/c mouse model [J].
Anitha, A. ;
Fletcher, Nicholas L. ;
Houston, Zachary H. ;
Thurecht, Kristofer J. ;
Grondahl, Lisbeth .
CARBOHYDRATE POLYMERS, 2021, 262
[9]   AGAROSE DOUBLE HELIX AND ITS FUNCTION IN AGAROSE-GEL STRUCTURE [J].
ARNOTT, S ;
FULMER, A ;
SCOTT, WE ;
DEA, ICM ;
MOORHOUSE, R ;
REES, DA .
JOURNAL OF MOLECULAR BIOLOGY, 1974, 90 (02) :269-&
[10]   Self-cross-linkable hydrogels composed of partially oxidized alginate and gelatin for myocardial infarction repair [J].
Bai, Xiuping ;
Fang, Rui ;
Zhang, Song ;
Shi, Xinli ;
Wang, Zeli ;
Chen, Xiongbiao ;
Yang, Jing ;
Hou, Xiaolu ;
Nie, Yongzhan ;
Li, Yu ;
Tian, Weiming .
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, 2013, 28 (02) :126-140