Preclinical Studies on Neural Stem/Progenitor Cell Therapy for Ischemic Stroke: A Systematic Review

被引：1

作者：

Zhang, Mengze ^{[1
]}

Wang, Kan ^{[1
]}

Xue, Chunran ^{[1
]}

Xie, Chong ^{[1
]}

Wang, Ze ^{[1
]}

Song, Yaying ^{[1
]}

Yu, Haojun ^{[1
]}

Hao, Yong ^{[1
]}

Guan, Yangtai ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Neurol, 160 Pujian Rd, Shanghai 200127, Peoples R China

来源：

CURRENT STEM CELL RESEARCH & THERAPY | 2023年 / 18卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Neural stem cells; transplantation; ischemic stroke; treatment outcome; animal experimentation; safety; IMPROVE FUNCTIONAL RECOVERY; STEM-CELLS; TRANSPLANTATION THERAPY; CEREBRAL-ISCHEMIA; PROGENITOR CELLS; PRECURSOR CELLS; BRAIN; MOUSE; NEUROPROTECTION; SENSORIMOTOR;

D O I：

10.2174/1574888X17666220410221905

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Background Neural stem/progenitor cells (NSPCs) transplantation has been recognized in recent years as an effective strategy for the treatment of ischemic stroke. Several preclinical studies have demonstrated the feasibility, safety, and efficacy of NSPCs therapy. Methods We conducted a systematic review of the published literature in Pubmed reporting the use of NSPCs in preclinical studies between 2010 and 2021. Based on the articles reporting data, the key factors affecting efficacy were listed. Results A total of 71 preclinical studies, including 91 treatment arms, were identified. The results showed that several factors could influence the outcomes of NSPCs transplantation, including the type of donor cells, cell dose, time of administration after stroke, delivery route, and anesthetic. Treatment outcomes were measured by infarct volume, behavioral tests, and molecular and cellular level results. Conclusion Most of the preclinical studies reported statistically significant effects and very few adverse reactions. Transplantation of NSPCs for ischemic stroke still needs to be optimized for several key factors. A standardized treatment outcome assessment could ease the translation of evidence in clinical settings.

引用

页码：380 / 390

页数：11

共 63 条

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