Diagnosing Balamuthia mandrillaris amebic meningoencephalitis in a 64-year-old woman from the Southwest of China

被引：1

作者：

Yao, Suhua ^{[1
,2
]}

Chen, Xiaoting ^{[1
]}

Qian, Lian ^{[1
]}

Sun, Shizheng ^{[1
]}

Zhao, Chunjing ^{[1
]}

Bai, Zongkai ^{[1
]}

Chen, Zhaofang ^{[1
]}

Wu, Youcong ^{[1
,3
]}

机构：

[1] Dali Univ, Sch Basic Med Sci, Dept Med Microbiol & Immunol, Dali, Yunnan Province, Peoples R China

[2] Dali Univ, Affiliated Hosp 3, Dali, Yunnan province, Peoples R China

[3] Fudan Univ, Shanghai Med Coll, Sch Basic Med Sci, Key Lab Med Mol Virol,MOE,NHC, Shanghai, Peoples R China

来源：

PARASITES HOSTS AND DISEASES | 2023年 / 61卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Balamuthia mandrillaris; amebic encephalitis; amebic pneumonia; Southwest China; LEPTOMYXID-AMEBA; HEALTHY CHILD; ENCEPHALITIS; IDENTIFICATION; INFECTION; SAMPLES;

D O I：

10.3347/PHD.23039

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Balamuthia mandrillaris amebic encephalitis (BAE) can cause a fatal condition if diagno-sis is delayed or effective treatment is lacking. Patients with BAE have been previously reported in 12 provinces of China, with skin lesions being the primary symptom and en-cephalitis developing after several years. However, a significantly lower number of cases has been reported in Southwest China. Here we report an aggressive BAE case of a 64 -year-old woman farmer with a history of skin lesions on her left hand. She was admitted to our hospital due to symptoms of dizziness, headache, cough, vomiting, and gait in-stability. She was initially diagnosed with syphilitic meningoencephalitis and received a variety of empirical treatment that failed to improve her symptoms. Finally, she was di-agnosed with BAE combined with amebic pneumonia using next-generation sequenc-ing (NGS), qRT-PCR, sequence analysis, and imaging studies. She died approximately 3 weeks after the onset. This case highlights that the rapid development of encephalitis can be a prominent clinical manifestation of Balamuthia mandrillaris infection.

引用

页码：183 / +

页数：12