Eco-Friendly Extraction of Green Coffee Oil for Industrial Applications: Its Antioxidant, Cytotoxic, Clonogenic, and Wound Healing Properties

被引:3
|
作者
Dias, Lucas D. [1 ,4 ]
Carbinatto, Fernanda Mansano [1 ]
Almeida, Isabelle da Silveira [1 ]
Blanco, Kate C. [1 ]
Marquele-Oliveira, Franciane [2 ]
Munari, Carla Carolina [2 ]
Bagnato, Vanderlei Salvador [1 ,3 ]
机构
[1] Univ Sao Paulo, Sao Carlos Inst Phys, BR-13560970 Sao Carlos, SP, Brazil
[2] Eleve Sci Res & Dev Innovat Lab, BR-14056680 Ribeirao Preto, SP, Brazil
[3] Texas A&M Univ, Dept Biomed Engn, College Stn, TX 77843 USA
[4] Univ Evangelica Goias, Lab Novos Mat, BR-75083515 Anapolis, GO, Brazil
来源
FERMENTATION-BASEL | 2023年 / 9卷 / 04期
基金
巴西圣保罗研究基金会;
关键词
green coffee oil; In vitro biological assay; cytotoxicity; wound healing; DPPH; IN-VITRO; DITERPENES; FORMULATIONS; PRODUCTS; ARABICA;
D O I
10.3390/fermentation9040370
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The development of natural oil-based cosmetic and pharmaceutical products presents great scientific and commercial interest. Herein, we aimed to extract green coffee oil from Arabic coffee by a sustainable cold-pressing method. Furthermore, this work aimed to characterize the obtained green coffee oil by Fourier-Transform Infrared (FT-IR) and ultraviolet-visible spectroscopies (UV-Vis), peroxide analysis, and fatty acids profile by gas chromatography-mass spectrometry (GC-MS). Moreover, the functional and biological properties of the obtained green coffee oil and a green-coffee oil-based commercial product (Energy up((R)), Dermociencia) were investigated. The green coffee oil presented linoleic and palmitic acids as the major fatty acids showing 44.8% and 35.4%, respectively. Moreover, this green coffee oil presented an antioxidant activity (EC50 7.64 mg/mL) and an absence of cytotoxic effects in keratinocyte cultures treated with up to 20 mg/mL. The obtained green coffee oil showed wound healing properties as well as clonogenic efficiency, a biological potential to induce the proliferative and migratory capacity of cells of human skin keratinocytes at 2.5 mg/mL. The samples presented high antioxidant activity and the absence of a cytotoxic effect, suggesting that green coffee oil is a promising natural product for cosmetic applications with wound healing properties. These results open new ways for the use of green coffee oil for the development of cosmetic and pharmaceutics natural-based products.
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页数:13
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