Cell-Membrane-Coated Nanoparticles for Targeted Drug Delivery to the Brain for the Treatment of Neurological Diseases

被引：15
作者：
Li, Jianzhuang [1 ]
Wei, Yanhao [1 ]
Zhang, Chunlin [1 ]
Bi, Rentang [1 ]
Qiu, Yanmei [1 ]
Li, Yanan [1 ]
Hu, Bo [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Neurol, Wuhan 430022, Peoples R China
来源：
PHARMACEUTICS | 2023年 / 15卷 / 02期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
neurological diseases; cell membrane; nanoparticles; drug delivery; blood-brain barrier; targeting; NANOSTRUCTURED LIPID CARRIERS; MACROPHAGE DELIVERY; ISCHEMIC-STROKE; MURINE MODEL; RESOLVIN D2; BARRIER; THERAPY; SYSTEM; MECHANISMS; PROGRESS;
D O I：
10.3390/pharmaceutics15020621
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Neurological diseases (NDs) are a significant cause of disability and death in the global population. However, effective treatments still need to be improved for most NDs. In recent years, cell-membrane-coated nanoparticles (CMCNPs) as drug-targeting delivery systems have become a research hotspot. Such a membrane-derived, nano drug-delivery system not only contributes to avoiding immune clearance but also endows nanoparticles (NPs) with various cellular and functional mimicries. This review article first provides an overview of the function and mechanism of single/hybrid cell-membrane-derived NPs. Then, we highlight the application and safety of CMCNPs in NDs. Finally, we discuss the challenges and opportunities in the field.
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页数：21
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