The association of wound factors and symptoms of fatigue and pain with wound healing in chronic venous leg ulcers

被引:5
作者
Kim, Junglyun [1 ,2 ]
Stechmiller, Joyce [2 ]
Weaver, Michael [2 ]
Gibson, Daniel J. [3 ]
Horgas, Ann [2 ]
Kelly, Debra L. [2 ]
Lyon, Debra E. [2 ]
机构
[1] Chungnam Natl Univ, Coll Nursing, Daejeon, South Korea
[2] Univ Florida, Coll Nursing, Dept Biobehav Nursing Sci, 1225 Ctr Dr, Gainesville, FL 32610 USA
[3] Univ Alabama, Capstone Coll Nursing, Tuscaloosa, AL USA
关键词
chronic venous leg ulcers; CRP; fatigue; MMPs; wound healing; QUALITY-OF-LIFE; R PACKAGE; ADVANCED CANCER; FLUID; INFLAMMATION; MANAGEMENT; IDENTIFICATION; INTERLEUKIN-6; PREVALENCE; ACTIVATION;
D O I
10.1111/iwj.13966
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
The purpose of this study was: (1) to characterise the association of wound area, wound exudate C-reactive protein (CRP), broad-spectrum matrix metalloprotease protein (MMPs), and symptoms of fatigue and pain in individuals with chronic venous leg ulcers (CVLUs) over time and (2) to identify factors associated with the wound healing trajectory in CVLUs. Seventy four participants with CVLU who received weekly sharp debridement were recruited from a wound care clinic during the 8-week study period. To examine associations among wound CRP, MMPs, pain, fatigue, and wound healing trajectory over time, we calculated Bayes factors (BF) based on a linear mixed model. The mean age of participants was 71.8 (SD = 9.8) and the mean wound area was 2278 mm(2) (SD = 7085 mm(2)) at baseline. Higher fatigue was strongly associated with higher MMPs (BF = 9, 95% HDI: [-.05, .43]), lower CRP (BF = 11, 95% HDI: [-.02, .002]), and large areas of wound (BF = 20, 95% HDI: [-.001, .01]). Higher CRP and MMPs activity in wound exudate and higher fatigue were associated with a larger wound area. To facilitate wound healing, clinicians need to utilise the multifactorial approach, which includes wound treatment and management of symptoms such as pain and fatigue, because of the molecular and psycho-behavioural factors involved in wound healing.
引用
收藏
页码:1098 / 1111
页数:14
相关论文
共 95 条
[11]   A gene signature of nonhealing venous ulcers: Potential diagnostic markers [J].
Charles, Carlos A. ;
Tomic-Canic, Marjana ;
Vincek, Vladimir ;
Nassiri, Mehdi ;
Stojadinovic, Olivera ;
Eaglstein, William H. ;
Kirsner, Robert S. .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2008, 59 (05) :758-771
[12]   A NEW METHOD OF CLASSIFYING PROGNOSTIC CO-MORBIDITY IN LONGITUDINAL-STUDIES - DEVELOPMENT AND VALIDATION [J].
CHARLSON, ME ;
POMPEI, P ;
ALES, KL ;
MACKENZIE, CR .
JOURNAL OF CHRONIC DISEASES, 1987, 40 (05) :373-383
[13]   Venous leg ulceration pathophysiology and evidence based treatment [J].
Chi, Yung-Wei ;
Raffetto, Joseph D. .
VASCULAR MEDICINE, 2015, 20 (02) :168-181
[14]   A systematic review of cytokines in chronic fatigue syndrome/myalgic encephalomyelitis/systemic exertion intolerance disease (CFS/ME/SEID) [J].
Corbitt, Matthew ;
Eaton-Fitch, Natalie ;
Staines, Donald ;
Cabanas, Helene ;
Marshall-Gradisnik, Sonya .
BMC NEUROLOGY, 2019, 19 (01)
[15]   Relationship between weight loss and parameters of skeletal muscle function in patients with advanced cancer and fatigue [J].
Cresta Morgado, P. ;
Giorlando, A. ;
Castro, M. ;
Navigante, A. .
SUPPORTIVE CARE IN CANCER, 2016, 24 (09) :3961-3966
[16]   Biochemical and Biological Attributes of Matrix Metalloproteinases [J].
Cui, Ning ;
Hu, Min ;
Khalil, Raouf A. .
MATRIX METALLOPROTEINSES AND TISSUE REMODELING IN HEALTH AND DISEASE: CARDIOVASCULAR REMODELING, 2017, 147 :1-73
[17]   Circulatory levels of B-cell activating factor of the TNF family in patients with diabetic foot ulcer: Association with disease progression [J].
Dhamodharan, Umapathy ;
Teena, Rajan ;
Kumar, Ramachandran Vimal ;
Changam, Sheela Sasikumar ;
Ramkumar, Kunka Mohanram ;
Rajesh, Kesavan .
WOUND REPAIR AND REGENERATION, 2019, 27 (05) :442-449
[18]  
Dissemond J, 2020, J WOUND CARE, V29, P102, DOI 10.12968/jowc.2020.29.2.102
[19]   Chronic Venous Insufficiency [J].
Eberhardt, Robert T. ;
Raffetto, Joseph D. .
CIRCULATION, 2014, 130 (04) :333-346
[20]   Identification of Symptom Clusters in Patients With Chronic Venous Leg Ulcers [J].
Edwards, Helen ;
Finlayson, Kathleen ;
Skerman, Helen ;
Alexander, Kimberly ;
Miaskowski, Christine ;
Aouizerat, Bradley ;
Gibb, Michelle .
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 2014, 47 (05) :867-875