Pathogenesis of Depression in Alzheimer's Disease

被引：4

作者：

Zhan, Qingyang ^{[1
]}

Kong, Fanyi ^{[1
]}

Shao, Shuai ^{[1
]}

Zhang, Bo ^{[1
]}

Huang, Shuming ^{[1
]}

机构：

[1] Heilongjiang Univ Chinese Med, Inst Chinese Med, Harbin 150040, Peoples R China

来源：

NEUROCHEMICAL RESEARCH | 2024年 / 49卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Alzheimer's Disease; Depression; Serotonin; Neuro-inflammation; HPA axis; BDNF; Glutamate; Hippocampal atrophy; AMYLOID-BETA OLIGOMERS; LONG-TERM DEPRESSION; D-ASPARTATE RECEPTOR; NEUROTROPHIC FACTOR; OLDER-ADULTS; MOUSE MODEL; HIPPOCAMPAL; DOPAMINE; NEUROGENESIS; DYSFUNCTION;

D O I：

10.1007/s11064-023-04061-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Depression is a prevalent occurrence among Alzheimer's disease (AD) patients, yet its underlying mechanism remains unclear. Recent investigations have revealed that several pathophysiological changes associated with Alzheimer's disease can lead to mood disorders. These alterations include irregularities in monoamine neurotransmitters, disruptions in glutamatergic synaptic transmission, neuro-inflammation, dysfunction within the hypothalamic-pituitary-adrenocortical (HPA) axis, diminished levels of brain-derived neurotrophic factor (BDNF), and hippocampal atrophy. This review consolidates research findings from pertinent fields to elucidate the mechanisms underlying depression in Alzheimer's disease, aiming to provide valuable insights for the study of its mechanisms and clinical treatment.

引用

页码：548 / 556

页数：9

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