Divergent Pathogenesis and Transmission of Highly Pathogenic Avian Influenza A(H5N1) in Swine

被引：15

作者：

Arruda, Bailey ^{[1
,3
]}

Baker, Amy L. Vincent ^{[1
]}

Buckley, Alexandra ^{[1
]}

Anderson, Tavis K. ^{[1
]}

Torchetti, Mia ^{[2
]}

Bergeson, Nichole Hines ^{[2
]}

Killian, Mary Lea ^{[2
]}

Lantz, Kristina ^{[2
]}

机构：

[1] Agr Res Serv, Ames, IA USA

[2] Anim & Plant Hlth Inspection Serv, Ames, IA USA

[3] USDA, Natl Dis Ctr, 1920 Dayton Ave, Ames, IA 50010 USA

来源：

EMERGING INFECTIOUS DISEASES | 2024年 / 30卷 / 04期

基金：

美国国家卫生研究院;

关键词：

CONTACT TRANSMISSION; VIRUS H5N1; A VIRUSES; PIGS; EVOLUTION; RECEPTOR; INFECTION; SELECTION;

D O I：

10.3201/eid3004.231141

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Highly pathogenic avian influenza (HPAI) viruses have potential to cross species barriers and cause pandemics. Since 2022, HPAI A(H5N1) belonging to the goose/ Guangdong 2.3.4.4b hemagglutinin phylogenetic clade have infected poultry, wild birds, and mammals across North America. Continued circulation in birds and infection of multiple mammalian species with strains possessing adaptation mutations increase the risk for infection and subsequent reassortment with influenza A viruses endemic in swine. We assessed the susceptibility of swine to avian and mammalian HPAI H5N1 clade 2.3.4.4b strains using a pathogenesis and transmission model. All strains replicated in the lung of pigs and caused lesions consistent with influenza A infection. However, viral replication in the nasal cavity and transmission was only observed with mammalian isolates. Mammalian adaptation and reassortment may increase the risk for incursion and transmission of HPAI viruses in feral, backyard, or commercial swine.

引用

页码：738 / 751

页数：14

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