Triterpenoids from Juglans mandshurica with anti-hyaluronidase activities

被引：0

作者：

Qi, Ze-Chen ^{[1
]}

Chen, Qiu-Han ^{[2
]}

Xu, Zeng ^{[1
]}

Yang, Chen ^{[2
]}

机构：

[1] Naval Med Univ, Changzheng Hosp, Dept Orthoped, Shanghai 200003, Peoples R China

[2] Shanghai Int High Sch BANZ, Shanghai 200003, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2024年 / 26卷 / 07期

关键词：

Juglans mandshurica; Juglandaceae; triterpenoids; anti-hyaluronidase activities; STEM-BARK; CONSTITUENTS; EXTRACTS; ROOTS;

D O I：

10.1080/10286020.2024.2327514

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Phytochemical study on 90% ethanol extract from the green walnut husks of Juglans mandshurica Maxim. resulted into the isolation of three undescribed triterpenoids, juglansmanoids A-C (1-3). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (H-1-H-1 COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated components were evaluated in vitro for anti-hyaluronidase activities. As a result, triterpenoid 1 exhibited potent anti-hyaluronidase activity (IC50 = 9.78 mu g/ml) three times more than the positive control drug oleanolic acid (IC50 = 40.12 mu g/ml). [GRAPHICS] .

引用

页码：773 / 779

页数：7

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