Triterpenoids from Juglans mandshurica with anti-hyaluronidase activities

被引：0

作者：

Qi, Ze-Chen ^{[1
]}

Chen, Qiu-Han ^{[2
]}

Xu, Zeng ^{[1
]}

Yang, Chen ^{[2
]}

机构：

[1] Naval Med Univ, Changzheng Hosp, Dept Orthoped, Shanghai 200003, Peoples R China

[2] Shanghai Int High Sch BANZ, Shanghai 200003, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2024年 / 26卷 / 07期

关键词：

Juglans mandshurica; Juglandaceae; triterpenoids; anti-hyaluronidase activities; STEM-BARK; CONSTITUENTS; EXTRACTS; ROOTS;

D O I：

10.1080/10286020.2024.2327514

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Phytochemical study on 90% ethanol extract from the green walnut husks of Juglans mandshurica Maxim. resulted into the isolation of three undescribed triterpenoids, juglansmanoids A-C (1-3). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (H-1-H-1 COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated components were evaluated in vitro for anti-hyaluronidase activities. As a result, triterpenoid 1 exhibited potent anti-hyaluronidase activity (IC50 = 9.78 mu g/ml) three times more than the positive control drug oleanolic acid (IC50 = 40.12 mu g/ml). [GRAPHICS] .

引用

页码：773 / 779

页数：7

共 19 条

[1]

[Anonymous], 2018, Nat. Prod. Res

[2] Secondary metabolite profiling, cytotoxicity, anti-inflammatory potential and in vitro inhibitory activities of Nardostachys jatamansi on key enzymes linked to hyperglycemia, hypertension and cognitive disorders [J].

Bose, Biswajit ;

Tripathy, Debabrata ;

Chatterjee, Anupam ;

Tandon, Pramod ;

Kumaria, Suman .

PHYTOMEDICINE, 2019, 55 :58-69

[3] Juglanin suppresses fibrosis and inflammation response caused by LPS in acute lung injury [J].

Dong, Ze-Wu ;

Yuan, Yu-Fang .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2018, 41 (06) :3353-3365

[4] Antioxidative polyphenols from walnuts (Juglans regia L.) [J].

Fukuda, T ;

Ito, H ;

Yoshida, T .

PHYTOCHEMISTRY, 2003, 63 (07) :795-801

[5] Photoprotection and Antiaging Activity of Extracts from Honeybush (Cyclopia sp.)-In Vitro Wound Healing and Inhibition of the Skin Extracellular Matrix Enzymes: Tyrosinase, Collagenase, Elastase and Hyaluronidase [J].

Hering, Anna ;

Stefanowicz-Hajduk, Justyna ;

Gucwa, Magdalena ;

Wielgomas, Bartosz ;

Ochocka, Jadwiga Renata .

PHARMACEUTICS, 2023, 15 (05)

[6] New naphthalenyl glucosides from the roots of Juglans mandshurica [J].

Joe, YK ;

Son, JK ;

Park, SH ;

Lee, IJ ;

Moon, DC .

JOURNAL OF NATURAL PRODUCTS, 1996, 59 (02) :159-160

[7] Three new compounds from the roots of Juglans mandshurica Maxim [J].

Li, Jing ;

Xu, Ping-Sheng ;

Zou, Zhen-Xing ;

Zou, Hui ;

Long, Hong-Ping ;

Tan, Lei-Hong ;

Liu, Rui-Huan ;

Wang, Yi-Kun ;

Xu, Kang-Ping ;

Tan, Gui-Shan .

PHYTOCHEMISTRY LETTERS, 2017, 20 :40-44

[8] Alkaloids from Juglans Mandshurica maxim induce distinctive cell death in hepatocellular carcinoma cells [J].

Lou, Li-Li ;

Cheng, Zhuo-Yang ;

Guo, Rui ;

Yao, Guo-Dong ;

Song, Shao-Jiang .

NATURAL PRODUCT RESEARCH, 2019, 33 (06) :911-914

[9] Studies on the constituents of Juglans species.: I.: Structural determination of (4S)- and (4R)-4-hydroxy-α-tetralone derivatives from the fruit of Juglans mandshurica MAXIM. var. sieboldiana MAKINO [J].

Machida, K ;

Matsuoka, E ;

Kasahara, T ;

Kikuchi, M .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2005, 53 (08) :934-937

[10]

Meshkini A, 2017, J ACUPUNCT MERIDIAN, V10, P193, DOI 10.1016/j.jams.2017.02.007

← 1 2 →