Association between serum homocysteine and postoperative acute kidney injury in patients undergoing cardiac surgery

被引：2

作者：

Li, Zheng-Rong ^{[1
]}

Liu, Cun-Fei ^{[2
]}

Guo, De-Qun ^{[2
]}

Wei, Yan-Jin ^{[2
]}

机构：

[1] Linyi Peoples Hosp, Dept Pharm, Linyi 276000, Shandong, Peoples R China

[2] Linyi Peoples Hosp, Dept Cardiol Med Ctr, Linyi 276000, Shandong, Peoples R China

来源：

BIOMARKERS IN MEDICINE | 2024年 / 18卷 / 02期

关键词：

acute kidney injury; cardiac surgery; homocysteine; HYPERHOMOCYSTEINEMIA; RISK; POPULATION; DISEASE; DAMAGE;

D O I：

10.2217/bmm-2023-0611

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background: To explore the relationship between homocysteine (Hcy) and cardiac surgery-associated acute kidney injury (AKI). Methods: A total of 944 patients who underwent cardiac surgery were enrolled. The association between Hcy levels and the risk of cardiac surgery-associated AKI was evaluated. Results: A total of 135 patients were diagnosed with AKI and the prevalence of AKI was 14.30%. The AKI group had significantly higher levels of Hcy compared with the non-AKI group (16.90 vs 13.56 umol/l; p < 0.001). The incidence rates of AKI increased from 7.2% to 26.72% across increasing Hcy quartiles (p < 0.001). Compared with the first Hcy quartile group, the odds ratio of cardiac surgery-associated AKI was 4.43 (95% CI: 2.27-8.66) in the highest Hcy group. Conclusion: Elevated Hcy level is an independent risk factor for cardiac surgery-associated AKI.

引用

页码：51 / 57

页数：7

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