The Intricate Dance of Infections and Autoimmunity: An Interesting Paradox

被引：1
|
作者：
Rao, Anand Prahalad [1 ]
Patro, Debasis [1 ]
机构：
[1] Manipal Hosp, Dept Pediat Rheumatol, HAL Airport Rd, Bengaluru, Karnataka, India
来源：
INDIAN JOURNAL OF PEDIATRICS | 2024年 / 91卷 / 09期
关键词：
Autoimmune disease; Inborn errors of immunity; Molecular mimicry; Bystander activation; Epitope spreading; EPSTEIN-BARR-VIRUS; CHILDREN; SUSCEPTIBILITY; SARS-COV-2; DISEASES;
D O I：
10.1007/s12098-023-04928-8
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Besides genetic susceptibility, infections due to viruses, bacteria and protozoa have been implicated in the development of autoimmune diseases (AD). AD can be triggered in a genetically susceptible individual by infections that disrupt immunological tolerance towards self-antigens. Pathogens can initiate autoimmunity by way of molecular mimicry, bystander activation, epitope spreading or persistent infection with polyclonal activation. This review covers two main topics: (i) the mechanisms by which an infectious agent can trigger or worsen autoimmunity; and (ii) the correlation between specific infectious agents and AD in humans with special emphasis on multisystem inflammatory syndrome in children (MIS-C).
引用
收藏
页码：941 / 948
页数：8
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