Sodium homeostasis and signalling: The core and the hub of astrocyte function

被引：13
作者：
Rose, Christine R. [1 ]
Verkhratsky, Alexej [2 ,3 ,4 ,5 ,6 ]
机构：
[1] Heinrich Heine Univ Dusseldorf, Inst Neurobiol, Fac Math & Nat Sci, D-40225 Dusseldorf, Germany
[2] Univ Manchester, Fac Biol Med & Hlth, Manchester M13 9PT, England
[3] Basque Fdn Sci, Achucarro Ctr Neurosci, IKERBASQUE, Bilbao 48011, Spain
[4] China Med Univ, Sch Forens Med, Dept Forens Analyt Toxicol, Shenyang, Peoples R China
[5] Chengdu Univ Tradit Chinese Med, Int Collaborat Ctr Big Sci Plan Purinerg Signaling, Chengdu, Peoples R China
[6] State Res Inst Ctr Innovat Med, Dept Stem Cell Biol, LT-01102 Vilnius, Lithuania
来源：
CELL CALCIUM | 2024年 / 117卷
关键词：
Astrocyte; Na plus signalling; SLC transporters; Na plus /K plus pump; pH regulation; Stroke; Hepatic encephalopathy; METHYL-D-ASPARTATE; MOUSE CORTICAL ASTROCYTES; GLIAL-CELLS; EXTRACELLULAR POTASSIUM; GLUTAMATE TRANSPORTERS; INTRACELLULAR SODIUM; GLYCINE TRANSPORTERS; K+ CHANNELS; RECEPTOR ACTIVATION; CL-COTRANSPORTER;
D O I：
10.1016/j.ceca.2023.102817
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Neuronal activity and neurochemical stimulation trigger spatio-temporal changes in the cytoplasmic concentration of Na+ ions in astrocytes. These changes constitute the substrate for Na+ signalling and are fundamental for astrocytic excitability. Astrocytic Na+ signals are generated by Na+ influx through neurotransmitter transporters, with primary contribution of glutamate transporters, and through cationic channels; whereas recovery from Na+ transients is mediated mainly by the plasmalemmal Na+/K+ ATPase. Astrocytic Na+ signals regulate the activity of plasmalemmal transporters critical for homeostatic function of astrocytes, thus providing real-time coordination between neuronal activity and astrocytic support.
引用
收藏
页数：15
相关论文
共 50 条
[21]   A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve [J].
Wallace, VA ;
Raff, MC .
DEVELOPMENT, 1999, 126 (13) :2901-2909
[22]   The role of extracellular glutamate homeostasis dysregulated by astrocyte in epileptic discharges: a model evidence [J].
Li, Duo ;
Li, Sihui ;
Pan, Min ;
Li, Qiang ;
Song, Jiangling ;
Zhang, Rui .
COGNITIVE NEURODYNAMICS, 2024, 18 (02) :485-502
[23]   Dynamism of an Astrocyte In Vivo: Perspectives on Identity and Function [J].
Poskanzer, Kira E. ;
Molofsky, Anna V. .
ANNUAL REVIEW OF PHYSIOLOGY, VOL 80, 2018, 80 :143-157
[24]   New Roles for Old Glue: Astrocyte Function in Synaptic Plasticity and Neurological Disorders [J].
Hussaini, Syed M. Q. ;
Jang, Mi Hyeon .
INTERNATIONAL NEUROUROLOGY JOURNAL, 2018, 22 :S106-S114
[25]   Glutamate-mediated astrocyte-to-neuron signalling in the rat dorsal horn [J].
Bardoni, Rita ;
Ghirri, Alessia ;
Zonta, Micaela ;
Betelli, Chiara ;
Vitale, Giovanni ;
Ruggieri, Valentina ;
Sandrini, Maurizio ;
Carmignoto, Giorgio .
JOURNAL OF PHYSIOLOGY-LONDON, 2010, 588 (05) :831-846
[26]   Astrocyte-mediated disruption of ROS homeostasis in Fragile X mouse model [J].
Vandenberg, Gregory G. ;
Dawson, Neal J. ;
Head, Alison ;
Scott, Graham R. ;
Scott, Angela L. .
NEUROCHEMISTRY INTERNATIONAL, 2021, 146
[27]   The role of extracellular glutamate homeostasis dysregulated by astrocyte in epileptic discharges: a model evidence [J].
Duo Li ;
Sihui Li ;
Min Pan ;
Qiang Li ;
Jiangling Song ;
Rui Zhang .
Cognitive Neurodynamics, 2024, 18 :485-502
[28]   Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration [J].
Neal, Matthew ;
Richardson, Jason R. .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2018, 1864 (02) :432-443
[29]   Multiple sclerosis: an immune attack on astrocyte-mediated ion and water homeostasis [J].
van der Knaap, Marjo S. ;
Min, Rogier .
NATURE REVIEWS NEUROLOGY, 2025, 21 (05) :283-289
[30]   Laquinimod Modulates Human Astrocyte Function and Dampens Astrocyte-Induced Neurotoxicity during Inflammation [J].
Colombo, Emanuela ;
Pascente, Rosaria ;
Triolo, Daniela ;
Bassani, Claudia ;
De Angelis, Anthea ;
Ruffini, Francesca ;
Ottoboni, Linda ;
Comi, Giancarlo ;
Martino, Gianvito ;
Farina, Cinthia .
MOLECULES, 2020, 25 (22)
12345