Ultrasound and clinicopathological characteristics of breast cancer for predicting axillary lymph node metastasis

被引：16

作者：

Bai, Xiaofang ^{[1
]}

Wang, Yunyue ^{[1
]}

Song, Ruxi ^{[1
]}

Li, Shangan ^{[1
]}

Song, Yan ^{[1
]}

Wang, Huan ^{[2
]}

Tong, Xiaoning ^{[3
]}

Wei, Wei ^{[1
]}

Ruan, Litao ^{[1
]}

Zhao, Qiaoling ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Ultrasound Med, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China

[2] Xi An Jiao Tong Univ, Dept Pain Med, Affiliated Hosp 1, Xian, Peoples R China

[3] Xi An Jiao Tong Univ, Dept Clin Lab, Affiliated Hosp 1, Xian, Peoples R China

来源：

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION | 2023年 / 85卷 / 02期

关键词：

Breast cancer; ultrasound; axillary lymph node metastasis; DISSECTION; WOMEN;

D O I：

10.3233/CH-231777

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVES: The goal of this study was to assess the clinicopathological and ultrasound (US) features of breast cancer for predicting the risk of axillary lymph node metastasis. METHODS: Patients with breast cancer were included in this retrospective, monocentric, observational study. Their preoperative ultrasound features, clinical data, laboratory results and postoperative pathologic results and immunophenotyping were collected. The association of these factors of breast cancer with axillary lymph node metastasis was evaluated by univariate and multivariate analysis. RESULTS: In this study, 471 patients diagnosed with breast cancer at the First Affiliated Hospital of Xi'an Jiaotong University between July 2016 and September 2019 were collected, with a total of 471 nodules, of which 231(49.0%) had axillary lymph node metastasis, and 240(51.0%) did not. The parameters of hyperechoic halo, posterior acoustic decrease, microcalcification, carcinogenic embryonic antigen (CEA), cancer antigen-153 (CA153), CK5/6 (+), Ki67 (>= 40%), AR (+) and histological grade (grade II and grade III) were significantly and independently associated with axillary lymph node metastasis (p < 0.05 for all). CONCLUSIONS: The combination of ultrasound features, tumor markers, pathology, and immunohistochemistry can predict axillary lymph node metastasis in breast cancer patients.

引用

页码：147 / 162

页数：16

共 14 条

[1] Axillary Lymph Node Dissection for Breast Cancer: Efficacy and Complication in Developing Countries [J].