Cancer Cell Membrane-Based Materials for Biomedical Applications

被引：4

作者：

Lu, Yongping ^{[1
,2
]}

Fan, Linming ^{[1
]}

Wang, Jun ^{[1
]}

Hu, Mingxiang ^{[1
]}

Wei, Baogang ^{[1
]}

Shi, Ping ^{[1
]}

Li, Jianshu ^{[3
,4
]}

Feng, Jinyan ^{[1
]}

Zheng, Yu ^{[5
]}

机构：

[1] Guangyuan Cent Hosp, Sci & Technologv Innovat Ctr, Guangyuan 628000, Peoples R China

[2] Guangyuan Cent Hosp, Guangyuan Key Lab Multifunct Med Hydrogel, Guangyuan 628000, Peoples R China

[3] Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Chengdu 610065, Peoples R China

[4] Sichuan Univ, West China Hosp Stomatol, Medx Ctr Mat, State Key Lab Oral Dis, Chengdu 610041, Peoples R China

[5] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China

来源：

SMALL | 2024年 / 20卷 / 07期

关键词：

biomedical applications; bionanoplasmic nanoplatforms; cancer cell membranes; cancer therapy; BIOMIMETIC NANOPARTICLES; PHOTOTHERMAL THERAPY; COATED NANOPARTICLES; CAMOUFLAGED NANOPARTICLES; TUMOR MICROENVIRONMENT; TARGETED STARVATION; CO-DELIVERY; EFFICIENT; DRUG; NANOSUSPENSIONS;

D O I：

10.1002/smll.202306540

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The nanodelivery system provides a novel direction for disease diagnosis and treatment; however, its delivery effectiveness is restricted by the short biological half-life and inadequate tumor targeting. The immune evasion properties and homologous targeting capabilities of natural cell membranes, particularly those of cancer cell membranes (CCM), have gained significant interest. The integration of CCM and nanoparticles has resulted in the emergence of CCM-based nanoplatforms (CCM-NPs), which have gained significant attention due to their unique properties. CCM-NPs not only prolong the blood circulation time of core nanoparticles, but also direct them for homologous tumor targeting. Herein, the history and development of CCM-NPs as well as how these platforms have been used for biomedical applications are discussed. The application of CCM-NPs for cancer therapy will be described in detail. Translational efforts are currently under way and further research to address key areas of need will ultimately be required to facilitate the successful clinical adoption of CCM-NPs. Herein, the history and development of cancer cell membranes (CCM)-based nanoplatforms (CCM-NPs) and how these platforms have been used for biomedical applications are discussed. TheCCM-NPs for cancer therapy will be described in detail. Translational efforts are currently under way and further research to address key areas of need will ultimately be required to facilitate the successful clinical adoption of CCM-NPs.image

引用

页数：48