Two pyrrole acids isolated from Phyllanthus emblica L. and their bioactivities

被引：0

作者：

Wang, Shu-Hui ^{[1
]}

Guo, Cong ^{[1
]}

Cui, Wen-Jin ^{[1
]}

Xu, Qing-Xia ^{[1
]}

Zhang, Jun ^{[1
]}

Jiang, Jin-Zhu ^{[1
]}

Liu, Yan ^{[1
]}

Chen, Sha ^{[1
]}

Chen, Chang ^{[1
]}

Cheng, Jin-Tang ^{[1
]}

Liu, An ^{[1
]}

机构：

[1] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China

来源：

NATURAL PRODUCTS AND BIOPROSPECTING | 2023年 / 13卷 / 01期

关键词：

Pyrrole acid; Phyllanthus emblica L; Lipid deposition; ATP-binding cassette transporter A1; RAW264.7; macrophages; FOAM CELL-FORMATION; HYDROLYZABLE TANNINS; PHENOLIC-COMPOUNDS; ANTIOXIDANT; FRUITS; POLYPHENOLS; INHIBITION; EXPRESSION; JUICE;

D O I：

10.1007/s13659-023-00393-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An undescribed pyrrole acid, 1-(4'-methoxy-4'-oxobutyl)-1 H-pyrrole-2,5-dicarboxylic acid (1) and one known pyrrole acid (2) were isolated from the fruits of Phyllanthus emblica. The structures of these compounds were elucidated via the comprehensive analyses of IR, HRESIMS, 1D and 2D spectroscopic data. A series of biological assays revealed that compounds 1 and 2 could inhibit LPS-induced over-production of nitric oxide (NO), interleukin-6 (IL-6), monocyte chemotactic protein 1 (MCP-1) and tumor necrosis factor-a (TNF-a) by reducing the phosphorylation of extracellular regulated protein kinases (ERK) and c-Jun N-terminal kinases (JNK) in RAW 264.7 cells. Additionally, compounds 1 and 2 were found to reduce lipid deposition and increase the mRNA expression of ATP-binding cassette transporter A1 in oxidized low-density lipoprotein-treated RAW264.7 macrophages.

引用

页数：9

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