Immune Reconstitution and Vaccinations in Multiple Myeloma: A Report From the 19th International Myeloma Society Annual Workshop

被引:3
作者
Terpos, Evangelos [1 ]
Neri, Paola [2 ,3 ]
van de Donk, Niels W. C. J. [4 ,5 ]
D'Agostino, Mattia [6 ]
Parekh, Samir [7 ,8 ]
Jagannath, Sundar [9 ,10 ]
Ludwig, Heinz [11 ]
Avigan, David E. [12 ,13 ]
Dhodapkar, Madhav V. [14 ]
Raje, Noopur S. [15 ,16 ]
机构
[1] Natl & Kapodistrian Univ Athens, Sch Med, Dept Clin Therapeut, Plasma Cell Dyscrasias Unit, Athens, Greece
[2] Tom Baker Canc Clin, Dept Med Oncol & Hematol, Calgary, AB, Canada
[3] Arnie Charbonneau Canc Res Inst, Calgary, AB, Canada
[4] Vrije Univ Amsterdam, Dept Hematol, Dept Hematol, Amsterdam UMC, Amsterdam, Netherlands
[5] Canc Ctr Amsterdam, Canc Biol & Immunol, Amsterdam, Netherlands
[6] Univ Torino, Div Hematol, SSD Clin Trial Oncoematol Mieloma Multiplo, Azienda Osped Univ Citta Salute e Sci Tor, Turin, Italy
[7] Icahn Sch Med Mt Sinai, Tisch Canc Inst, Dept Hematol & Med Oncol, New York, NY USA
[8] Icahn Sch Med Mt Sinai, Dept Oncol Sci, New York, NY USA
[9] Icahn Sch Med Mt Sinai, Dept Med Hematol & Med Oncol, New York, NY USA
[10] Icahn Sch Med Mt Sinai, Tish Canc Inst, New York, NY USA
[11] Wilhelminen Canc Res Inst, Dept Med 1, Ctr Med Oncol & Hematol Outpatient Dept & Palliat, Vienna, Austria
[12] Beth Israel Deaconess Med Ctr, Boston, MA USA
[13] Harvard Med Sch, Boston, MA USA
[14] Emory Univ, Winship Canc Inst, Dept Hematol & Med Oncol, Sch Med, Atlanta, GA USA
[15] Massachusetts Gen Hosp, Cellular Immunotherapy Program, Boston, MA USA
[16] Massachusetts Gen Hosp, Ctr Multiple Myeloma, Boston, MA USA
关键词
Bispecific; B-cell; CAR T-cell; Immune response; T-cell; T-CELL RESPONSES; PRECLINICAL ACTIVITY; BISPECIFIC ANTIBODY; BONE-MARROW; THERAPY; MICROENVIRONMENT; DARATUMUMAB; TRANSPLANT; OUTCOMES; IMPACT;
D O I
10.1016/j.clml.2023.03.009
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Given the significance of the immune system and the important role of therapies within the context of the immune system in plasma cell disorders, the International Myeloma Society annual workshop convened a session dedicated to this topic. A panel of experts covered various aspects of immune reconstitution and vaccination. The top oral presentations were highlighted and discussed. This is a report of the proceedings.
引用
收藏
页码:413 / 419
页数:7
相关论文
共 53 条
[31]   Prevention of infections including vaccination strategies in multiple myeloma [J].
Ludwig, Heinz ;
Kumar, Shaji .
AMERICAN JOURNAL OF HEMATOLOGY, 2023, 98 :S46-S62
[32]   COVID-19 vaccination in patients with multiple myeloma: a consensus of the European Myeloma Network [J].
Ludwig, Heinz ;
Sonneveld, Pieter ;
Facon, Thierry ;
San-Miguel, Jesus ;
Avet-Loiseau, Herve ;
Mohty, Mohamad ;
Mateos, Maria-Victoria ;
Moreau, Philippe ;
Cavo, Michele ;
Pawlyn, Charlotte ;
Zweegman, Sonja ;
Engelhardt, Monika ;
Driessen, Christoph ;
Cook, Gordon ;
Dimopoulos, Melitios A. ;
Gay, Francesca ;
Einsele, Hermann ;
Delforge, Michel ;
Caers, Jo ;
Weisel, Katja ;
Jackson, Graham ;
Garderet, Laurent ;
van de Donk, Niels ;
Leleu, Xavier ;
Goldschmidt, Hartmut ;
Beksac, Meral ;
Nijhof, Inger ;
Schreder, Martin ;
Abildgaard, Niels ;
Hajek, Roman ;
Zojer, Niklas ;
Kastritis, Efstathios ;
Broijl, Annemiek ;
Schjesvold, Fredrik ;
Boccadoro, Mario ;
Terpos, Evangelos .
LANCET HAEMATOLOGY, 2021, 8 (12) :E934-E946
[33]   Recommendations for vaccination in multiple myeloma: a consensus of the European Myeloma Network [J].
Ludwig, Heinz ;
Boccadoro, Mario ;
Moreau, Philippe ;
San-Miguel, Jesus ;
Cavo, Michele ;
Pawlyn, Charlotte ;
Zweegman, Sonja ;
Facon, Thierry ;
Driessen, Christoph ;
Hajek, Roman ;
Dimopoulos, Melitios A. ;
Gay, Francesca ;
Avet-Loiseau, Herve ;
Terpos, Evangelos ;
Zojer, Niklas ;
Mohty, Mohamad ;
Mateos, Maria-Victoria ;
Einsele, Hermann ;
Delforge, Michel ;
Caers, Jo ;
Weisel, Katja ;
Jackson, Graham ;
Garderet, Laurent ;
Engelhardt, Monika ;
van de Donk, Niels ;
Leleu, Xavier ;
Goldschmidt, Hartmut ;
Beksac, Meral ;
Nijhof, Inger ;
Abildgaard, Niels ;
Bringhen, Sara ;
Sonneveld, Pieter .
LEUKEMIA, 2021, 35 (01) :31-44
[34]   Teclistamab in Relapsed or Refractory Multiple Myeloma [J].
Moreau, Philippe ;
Garfall, Alfred L. ;
van de Donk, Niels W. C. J. ;
Nahi, Hareth ;
San-Miguel, Jesus F. ;
Oriol, Albert ;
Nooka, Ajay K. ;
Martin, Thomas ;
Rosinol, Laura ;
Chari, Ajai ;
Karlin, Lionel ;
Benboubker, Lotfi ;
Mateos, Maria-Victoria ;
Bahlis, Nizar ;
Popat, Rakesh ;
Besemer, Britta ;
Martinez-Lopez, Joaquin ;
Sidana, Surbhi ;
Delforge, Michel ;
Pei, Lixia ;
Trancucci, Danielle ;
Verona, Raluca ;
Girgis, Suzette ;
Lin, Shun X. W. ;
Olyslager, Yunsi ;
Jaffe, Mindy ;
Uhlar, Clarissa ;
Stephenson, Tara ;
Van Rampelbergh, Rian ;
Banerjee, Arnob ;
Goldberg, Jenna D. ;
Kobos, Rachel ;
Krishnan, Amrita ;
Usmani, Saad Z. .
NEW ENGLAND JOURNAL OF MEDICINE, 2022, 387 (06) :495-505
[35]   Second Booster BNT162b2 Restores SARS-CoV-2 Humoral Response in Patients With Multiple Myeloma, Excluding Those Under Anti-BCMA Therapy [J].
Ntanasis-Stathopoulos, Ioannis ;
Karalis, Vangelis ;
Gavriatopoulou, Maria ;
Malandrakis, Panagiotis ;
Sklirou, Aimilia D. D. ;
Eleutherakis-Papaiakovou, Evangelos ;
Migkou, Magdalini ;
Roussou, Maria ;
Fotiou, Despina ;
Alexopoulos, Harry ;
Theodorakakou, Foteini ;
Kastritis, Efstathios ;
Iconomidou, Vassiliki A. A. ;
Trougakos, Ioannis P. P. ;
Dimopoulos, Meletios A. A. ;
Terpos, Evangelos .
HEMASPHERE, 2022, 6 (08)
[36]   Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities [J].
Oben, Benedith ;
Froyen, Guy ;
Maclachlan, Kylee H. ;
Leongamornlert, Daniel ;
Abascal, Federico ;
Zheng-Lin, Binbin ;
Yellapantula, Venkata ;
Derkach, Andriy ;
Geerdens, Ellen ;
Diamond, Benjamin T. ;
Arijs, Ingrid ;
Maes, Brigitte ;
Vanhees, Kimberly ;
Hultcrantz, Malin ;
Manasanch, Elisabet E. ;
Kazandjian, Dickran ;
Lesokhin, Alexander ;
Dogan, Ahmet ;
Zhang, Yanming ;
Mikulasova, Aneta ;
Walker, Brian ;
Morgan, Gareth ;
Campbell, Peter J. ;
Landgren, Ola ;
Rummens, Jean-Luc ;
Bolli, Niccolo ;
Maura, Francesco .
NATURE COMMUNICATIONS, 2021, 12 (01)
[37]   Microenvironment immune reconstitution patterns correlate with outcomes after autologous transplant in multiple myeloma [J].
Parmar, Harsh ;
Gertz, Morie ;
Anderson, Emilie Ingrid ;
Kumar, Shaji ;
Kourelis, Taxiarchis, V .
BLOOD ADVANCES, 2021, 5 (07) :1797-1804
[38]   T-cell exhaustion induced by continuous bispecific molecule exposure is ameliorated by treatment-free intervals [J].
Philipp, Nora ;
Kazerani, Maryam ;
Nicholls, Alyssa ;
Vick, Binje ;
Wulf, Jan ;
Straub, Tobias ;
Scheurer, Michaela ;
Muth, Amelie ;
Hanel, Gerulf ;
Nixdorf, Daniel ;
Sponheimer, Monika ;
Ohlmeyer, Malte ;
Lacher, Sonja M. ;
Brauchle, Bettina ;
Marcinek, Anetta ;
Rohrbacher, Lisa ;
Leutbecher, Alexandra ;
Rejeski, Kai ;
Weigert, Oliver ;
von Bergwelt-Baildon, Michael ;
Theurich, Sebastian ;
Kischel, Roman ;
Jeremias, Irmela ;
Bucklein, Veit ;
Subklewe, Marion .
BLOOD, 2022, 140 (10) :1104-1118
[39]  
Qazilbash MH, 2022, BLOOD, V139, P1289, DOI 10.1182/blood.2020008493
[40]   Updated Clinical and Correlative Results from the Phase I CRB402 Study of the BCMA-Targeted CAR T Cell Therapy bb21217 in Patients with Relapsed and Refractory Multiple Myeloma [J].
Raje, Noopur S. ;
Shah, Nina ;
Jagannath, Sundar ;
Kaufman, Jonathan L. ;
Siegel, David S. ;
Munshi, Nikhil C. ;
Rosenblatt, Jacalyn ;
Lin, Yi ;
Jakubowiak, Andrzej ;
Timm, Alison ;
Yeri, Ashish ;
Martin, Nathan ;
Campbell, Timothy B. ;
Finney, Olivia ;
Truppel-Hartmann, Anna ;
Petrocca, Fabio ;
Berdeja, Jesus G. ;
Alsina, Melissa .
BLOOD, 2021, 138