Anti-Neuroinflammatory and Neuroprotective Effect of Intermedin B Isolated from the Curcuma longa L. via NF-κB and ROS Inhibition in BV2 Microglia and HT22 Hippocampal Cells

被引:3
|
作者
Lee, Hwan [1 ]
Liu, Zhiming [1 ]
Dong, Linsha [1 ]
Lee, Dae Young [2 ]
Yoon, Dahye [2 ]
Oh, Hyuncheol [3 ]
Kim, Youn-Chul [3 ]
An, Ren-Bo [4 ]
Lee, Dong-Sung [1 ]
机构
[1] Chosun Univ, Coll Pharm, Gwangju 61452, South Korea
[2] Rural Dev Adm RDA, Dept Herbal Crop Res, Natl Inst Hort & Herbal Sci, Eumseong 27709, South Korea
[3] Wonkwang Univ, Coll Pharm, Iksan 54538, South Korea
[4] Yanbian Univ, Coll Pharm, Yanji 133002, Peoples R China
关键词
Curcuma longa L; neurodegenerative disease; intermedin B; BV2; microglia; HT22; hippocampus; NITRIC-OXIDE; HEME OXYGENASE-1; DEMETHOXYCURCUMIN; SESQUITERPENOIDS; METABOLITES; DERIVATIVES; EXPRESSION; TOXICITY; PROTEINS; STRESS;
D O I
10.3390/ijms24087390
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Compounds derived from Curcuma longa L. (C. longa) have been extensively studied and reported to be effective and safe for the prevention and treatment of various diseases, but most research has been focused on curcuminoids derived from C. longa. As neurodegenerative diseases are associated with oxidation and inflammation, the present study aimed to isolate and identify active compounds other than curcuminoids from C. longa to develop substances to treat these diseases. Seventeen known compounds, including curcuminoids, were chromatographically isolated from the methanol extracts of C. longa, and their chemical structures were identified using 1D and 2D NMR spectroscopy. Among the isolated compounds, intermedin B exhibited the best antioxidant effect in the hippocampus and anti-inflammatory effect in microglia. Furthermore, intermedin B was confirmed to inhibit the nuclear translocation of NF-kappa B p-65 and I kappa B alpha, exerting anti-inflammatory effects and inhibiting the generation of reactive oxygen species, exerting neuroprotective effects. These results highlight the research value of active components other than curcuminoids in C. longa-derived compounds and suggest that intermedin B may be a promising candidate for the prevention of neurodegenerative diseases.
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页数:17
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