Anti-Neuroinflammatory and Neuroprotective Effect of Intermedin B Isolated from the Curcuma longa L. via NF-κB and ROS Inhibition in BV2 Microglia and HT22 Hippocampal Cells
被引:3
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作者:
Lee, Hwan
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机构:
Chosun Univ, Coll Pharm, Gwangju 61452, South KoreaChosun Univ, Coll Pharm, Gwangju 61452, South Korea
Lee, Hwan
[1
]
Liu, Zhiming
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h-index: 0
机构:
Chosun Univ, Coll Pharm, Gwangju 61452, South KoreaChosun Univ, Coll Pharm, Gwangju 61452, South Korea
Liu, Zhiming
[1
]
Dong, Linsha
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机构:
Chosun Univ, Coll Pharm, Gwangju 61452, South KoreaChosun Univ, Coll Pharm, Gwangju 61452, South Korea
Dong, Linsha
[1
]
Lee, Dae Young
论文数: 0引用数: 0
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机构:
Rural Dev Adm RDA, Dept Herbal Crop Res, Natl Inst Hort & Herbal Sci, Eumseong 27709, South KoreaChosun Univ, Coll Pharm, Gwangju 61452, South Korea
Lee, Dae Young
[2
]
Yoon, Dahye
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机构:
Rural Dev Adm RDA, Dept Herbal Crop Res, Natl Inst Hort & Herbal Sci, Eumseong 27709, South KoreaChosun Univ, Coll Pharm, Gwangju 61452, South Korea
Yoon, Dahye
[2
]
Oh, Hyuncheol
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机构:
Wonkwang Univ, Coll Pharm, Iksan 54538, South KoreaChosun Univ, Coll Pharm, Gwangju 61452, South Korea
Oh, Hyuncheol
[3
]
Kim, Youn-Chul
论文数: 0引用数: 0
h-index: 0
机构:
Wonkwang Univ, Coll Pharm, Iksan 54538, South KoreaChosun Univ, Coll Pharm, Gwangju 61452, South Korea
Kim, Youn-Chul
[3
]
An, Ren-Bo
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机构:
Yanbian Univ, Coll Pharm, Yanji 133002, Peoples R ChinaChosun Univ, Coll Pharm, Gwangju 61452, South Korea
An, Ren-Bo
[4
]
Lee, Dong-Sung
论文数: 0引用数: 0
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机构:
Chosun Univ, Coll Pharm, Gwangju 61452, South KoreaChosun Univ, Coll Pharm, Gwangju 61452, South Korea
Lee, Dong-Sung
[1
]
机构:
[1] Chosun Univ, Coll Pharm, Gwangju 61452, South Korea
[2] Rural Dev Adm RDA, Dept Herbal Crop Res, Natl Inst Hort & Herbal Sci, Eumseong 27709, South Korea
[3] Wonkwang Univ, Coll Pharm, Iksan 54538, South Korea
[4] Yanbian Univ, Coll Pharm, Yanji 133002, Peoples R China
Compounds derived from Curcuma longa L. (C. longa) have been extensively studied and reported to be effective and safe for the prevention and treatment of various diseases, but most research has been focused on curcuminoids derived from C. longa. As neurodegenerative diseases are associated with oxidation and inflammation, the present study aimed to isolate and identify active compounds other than curcuminoids from C. longa to develop substances to treat these diseases. Seventeen known compounds, including curcuminoids, were chromatographically isolated from the methanol extracts of C. longa, and their chemical structures were identified using 1D and 2D NMR spectroscopy. Among the isolated compounds, intermedin B exhibited the best antioxidant effect in the hippocampus and anti-inflammatory effect in microglia. Furthermore, intermedin B was confirmed to inhibit the nuclear translocation of NF-kappa B p-65 and I kappa B alpha, exerting anti-inflammatory effects and inhibiting the generation of reactive oxygen species, exerting neuroprotective effects. These results highlight the research value of active components other than curcuminoids in C. longa-derived compounds and suggest that intermedin B may be a promising candidate for the prevention of neurodegenerative diseases.
机构:
Yantai Univ, Minist Educ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Yantai 264005, Peoples R ChinaYantai Univ, Minist Educ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Yantai 264005, Peoples R China
Liu, Zhiming
Yoon, Chi-Su
论文数: 0引用数: 0
h-index: 0
机构:
Wonkwang Univ, Inst Pharmaceut Res & Dev, Coll Pharm, Iksan 54538, South KoreaYantai Univ, Minist Educ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Yantai 264005, Peoples R China
Yoon, Chi-Su
Lee, Hwan
论文数: 0引用数: 0
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机构:
Chosun Univ, Res Inst Pharmaceut Sci, Coll Pharm, Gwangju 61452, South KoreaYantai Univ, Minist Educ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Yantai 264005, Peoples R China
Lee, Hwan
Kim, Eunae
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h-index: 0
机构:
Chosun Univ, Res Inst Pharmaceut Sci, Coll Pharm, Gwangju 61452, South KoreaYantai Univ, Minist Educ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Yantai 264005, Peoples R China
Kim, Eunae
Yim, Joung Han
论文数: 0引用数: 0
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机构:
Korea Polar Res Inst, Div Polar Life Sci, Incheon 21990, South KoreaYantai Univ, Minist Educ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Yantai 264005, Peoples R China
Yim, Joung Han
Kim, Tai Kyoung
论文数: 0引用数: 0
h-index: 0
机构:
Korea Polar Res Inst, Div Polar Life Sci, Incheon 21990, South KoreaYantai Univ, Minist Educ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Yantai 264005, Peoples R China
Kim, Tai Kyoung
Oh, Hyuncheol
论文数: 0引用数: 0
h-index: 0
机构:
Wonkwang Univ, Inst Pharmaceut Res & Dev, Coll Pharm, Iksan 54538, South KoreaYantai Univ, Minist Educ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Yantai 264005, Peoples R China
Oh, Hyuncheol
Lee, Dong-Sung
论文数: 0引用数: 0
h-index: 0
机构:
Chosun Univ, Res Inst Pharmaceut Sci, Coll Pharm, Gwangju 61452, South KoreaYantai Univ, Minist Educ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Yantai 264005, Peoples R China
机构:
Chosun Univ, Coll Pharm, Gwangju 61452, South KoreaChosun Univ, Coll Pharm, Gwangju 61452, South Korea
Liu, Zhiming
Yoon, Chi-Su
论文数: 0引用数: 0
h-index: 0
机构:
Korea Res Inst Biosci & Biotechnol KRIBB, Nat Med Res Ctr, ZA-28116 Cheongju, South Africa
Univ Florida, Dept Chem, Gainesville, FL 32611 USAChosun Univ, Coll Pharm, Gwangju 61452, South Korea
Yoon, Chi-Su
Lee, Hwan
论文数: 0引用数: 0
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机构:
Chosun Univ, Coll Pharm, Gwangju 61452, South KoreaChosun Univ, Coll Pharm, Gwangju 61452, South Korea
Lee, Hwan
Lee, Hyeong-Kyu
论文数: 0引用数: 0
h-index: 0
机构:
Univ Florida, Dept Chem, Gainesville, FL 32611 USAChosun Univ, Coll Pharm, Gwangju 61452, South Korea
Lee, Hyeong-Kyu
Lee, Dong-Sung
论文数: 0引用数: 0
h-index: 0
机构:
Chosun Univ, Coll Pharm, Gwangju 61452, South KoreaChosun Univ, Coll Pharm, Gwangju 61452, South Korea
机构:
Korea Inst Oriental Med, Herbal Med Res Div, Daejeon 34054, South KoreaKorea Inst Oriental Med, Herbal Med Res Div, Daejeon 34054, South Korea
Kim, Yu Jin
Lim, Hye-Sun
论文数: 0引用数: 0
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机构:
Korea Inst Oriental Med, Herbal Med Res Div, Daejeon 34054, South KoreaKorea Inst Oriental Med, Herbal Med Res Div, Daejeon 34054, South Korea
Lim, Hye-Sun
Lee, Jun
论文数: 0引用数: 0
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机构:
Korea Inst Oriental Med, Herbal Med Res Div, Daejeon 34054, South Korea
Univ Sci & Technol, Korean Med Life Sci, Daejeon 34113, South KoreaKorea Inst Oriental Med, Herbal Med Res Div, Daejeon 34054, South Korea
Lee, Jun
Jeong, Soo-Jin
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机构:
Korea Inst Oriental Med, Herbal Med Res Div, Daejeon 34054, South Korea
Univ Sci & Technol, Korean Med Life Sci, Daejeon 34113, South KoreaKorea Inst Oriental Med, Herbal Med Res Div, Daejeon 34054, South Korea
机构:Shandong University,Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences
Qian Luo
Xiaoli Yan
论文数: 0引用数: 0
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机构:Shandong University,Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences
Xiaoli Yan
Larisa Bobrovskaya
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机构:Shandong University,Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences
Larisa Bobrovskaya
Mei Ji
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机构:Shandong University,Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences
Mei Ji
Huiqing Yuan
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机构:Shandong University,Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences
Huiqing Yuan
Hongxiang Lou
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机构:Shandong University,Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences
Hongxiang Lou
Peihong Fan
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机构:Shandong University,Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences
Peihong Fan
Molecular and Cellular Biochemistry,
2017,
428
: 129
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137
机构:
Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730000, Peoples R ChinaLanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730000, Peoples R China
Shi, Jiaotai
Wang, Chengbo
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机构:
Chinese Acad Sci, Lanzhou Inst Chem Phys, CAS Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China
Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R ChinaLanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730000, Peoples R China
Wang, Chengbo
Sang, Chunyan
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Chinese Acad Sci, Lanzhou Inst Chem Phys, CAS Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China
Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R ChinaLanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730000, Peoples R China
Sang, Chunyan
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Nsanzamahoro, Stanislas
Chai, Tian
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Chinese Acad Sci, Lanzhou Inst Chem Phys, CAS Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China
Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R ChinaLanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730000, Peoples R China
Chai, Tian
Wang, Jun
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Shandong Lab Yantai Adv Mat & Green Mfg, Yantai 264000, Peoples R ChinaLanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730000, Peoples R China
Wang, Jun
Yang, Aimei
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Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730000, Peoples R ChinaLanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730000, Peoples R China
Yang, Aimei
Yang, Junli
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Chinese Acad Sci, Lanzhou Inst Chem Phys, CAS Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China
Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R ChinaLanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730000, Peoples R China
机构:
Korea Inst Oriental Med, Herbal Med Res Div, 1672 Yuseongdaero, Daejeon 34054, South KoreaKorea Inst Oriental Med, Herbal Med Res Div, 1672 Yuseongdaero, Daejeon 34054, South Korea
Lim, Hye-Sun
Kim, Ohn-Soon
论文数: 0引用数: 0
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机构:
Korea Inst Oriental Med, Herbal Med Res Div, 1672 Yuseongdaero, Daejeon 34054, South KoreaKorea Inst Oriental Med, Herbal Med Res Div, 1672 Yuseongdaero, Daejeon 34054, South Korea
Kim, Ohn-Soon
Kim, Bu-Yeo
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Korea Inst Oriental Med, Herbal Med Res Div, 1672 Yuseongdaero, Daejeon 34054, South KoreaKorea Inst Oriental Med, Herbal Med Res Div, 1672 Yuseongdaero, Daejeon 34054, South Korea
Kim, Bu-Yeo
Jeong, Soo-Jin
论文数: 0引用数: 0
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机构:
Korea Inst Oriental Med, Herbal Med Res Div, 1672 Yuseongdaero, Daejeon 34054, South Korea
Univ Sci & Technol, Korean Med Life Sci, Daejeon, South KoreaKorea Inst Oriental Med, Herbal Med Res Div, 1672 Yuseongdaero, Daejeon 34054, South Korea
机构:
Wonkwang Univ, Coll Pharm, Inst Pharmaceut Res & Dev, Iksan 570749, South Korea
Wonkwang Univ, Coll Pharm, Iksan 570749, South KoreaWonkwang Univ, Coll Pharm, Inst Pharmaceut Res & Dev, Iksan 570749, South Korea
Yoon, Chi-Su
Kim, Dong-Cheol
论文数: 0引用数: 0
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机构:
Wonkwang Univ, Coll Pharm, Inst Pharmaceut Res & Dev, Iksan 570749, South Korea
Wonkwang Univ, Coll Pharm, Iksan 570749, South KoreaWonkwang Univ, Coll Pharm, Inst Pharmaceut Res & Dev, Iksan 570749, South Korea
Kim, Dong-Cheol
Lee, Dong-Sung
论文数: 0引用数: 0
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机构:
Wonkwang Univ, Hanbang Bodyfluid Res Ctr, Iksan 570749, South KoreaWonkwang Univ, Coll Pharm, Inst Pharmaceut Res & Dev, Iksan 570749, South Korea
Lee, Dong-Sung
Kim, Kyoung-Su
论文数: 0引用数: 0
h-index: 0
机构:
Wonkwang Univ, Coll Pharm, Inst Pharmaceut Res & Dev, Iksan 570749, South Korea
Wonkwang Univ, Coll Pharm, Iksan 570749, South KoreaWonkwang Univ, Coll Pharm, Inst Pharmaceut Res & Dev, Iksan 570749, South Korea
Kim, Kyoung-Su
Ko, Wonmin
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机构:
Wonkwang Univ, Coll Pharm, Inst Pharmaceut Res & Dev, Iksan 570749, South KoreaWonkwang Univ, Coll Pharm, Inst Pharmaceut Res & Dev, Iksan 570749, South Korea
Ko, Wonmin
Sohn, Jae Hak
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机构:
Silla Univ, Coll Med & Life Sci, Pusan 617736, South KoreaWonkwang Univ, Coll Pharm, Inst Pharmaceut Res & Dev, Iksan 570749, South Korea
Sohn, Jae Hak
Yim, Joung Han
论文数: 0引用数: 0
h-index: 0
机构:
KORDI, Korea Polar Res Inst, Inchon 406840, South KoreaWonkwang Univ, Coll Pharm, Inst Pharmaceut Res & Dev, Iksan 570749, South Korea
Yim, Joung Han
Kim, Youn-Chul
论文数: 0引用数: 0
h-index: 0
机构:
Wonkwang Univ, Coll Pharm, Inst Pharmaceut Res & Dev, Iksan 570749, South KoreaWonkwang Univ, Coll Pharm, Inst Pharmaceut Res & Dev, Iksan 570749, South Korea
Kim, Youn-Chul
Oh, Hyuncheol
论文数: 0引用数: 0
h-index: 0
机构:
Wonkwang Univ, Coll Pharm, Inst Pharmaceut Res & Dev, Iksan 570749, South KoreaWonkwang Univ, Coll Pharm, Inst Pharmaceut Res & Dev, Iksan 570749, South Korea